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Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (His tag) Protein

IL6RA Spezies: Human Wirt: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE. Active
Pubmed (1 reference)
Produktnummer ABIN2181394
$346.50
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Lieferung in 11 Werktagen
  • Target Alle IL6RA Proteine anzeigen
    IL6RA
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 20-365
    Spezies
    • 9
    • 4
    • 3
    • 1
    Human
    Quelle
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses IL6RA Protein ist gelabelt mit His tag.
    Sequenz
    AA 20-365
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 40 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >92 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Tanemura, Mochizuki, Kumachi, Nemoto: "Easy and rapid binding assay for functional analysis of disulfide-containing peptides by a pull-down method using a puromycin-linker and a cell-free translation system." in: Biology, Vol. 4, Issue 1, pp. 161-72, (2015) (PubMed).

  • Target
    IL6RA
    Andere Bezeichnung
    IL-6 R alpha (IL6RA Produkte)
    Synonyme
    IL6R1, Il6ra, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80, IL-6R, Il6r, interleukin 6 receptor, interleukin 6 receptor, alpha, Il6r, IL6R, Il6ra
    Hintergrund
    Interleukin 6 receptor (IL6R) is also known as CD126 (Cluster of Differentiation 126) , is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL6R is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. IL6R subunit also shared by many other cytokines. The soluble form of IL6R arises from proteolytic cleavage of membrane-bound IL6Rα, and acts agonistically by making the IL6 ligand accessible to the signal transducer gp130. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis, and it has been reported that a humanized anti-IL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases. Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor.
    Molekulargewicht
    39.4 kDa
    NCBI Accession
    NP_000556
    Pathways
    JAK-STAT Signalweg, Autophagie, Growth Factor Binding, Cancer Immune Checkpoints
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