IL6RA Protein (His tag)

Produktnummer ABIN7320911

Produktdetails

Target: IL6RA (Interleukin 6 Receptor, alpha (IL6RA))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses IL6RA Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse IL-6 Receptor Subunit alpha/IL-6RA/CD126 (C-6His)

Sequenz: Leu20-Pro364

Produktmerkmale: Recombinant Mouse Interleukin-6 receptor subunit alpha is produced by our Mammalian expression system and the target gene encoding Leu20-Pro364 is expressed with a 6His tag at the C-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL6RA (Interleukin 6 Receptor, alpha (IL6RA))

Andere Bezeichnung: IL-6 Receptor Subunit alpha/IL-6RA/CD126 (IL6RA Produkte)

Synonyme: IL6R1 Protein, Il6ra Protein, CD126 Protein, IL-6R-1 Protein, IL-6RA Protein, IL6Q Protein, IL6RA Protein, IL6RQ Protein, gp80 Protein, IL-6R Protein, Il6r Protein, interleukin 6 receptor Protein, interleukin 6 receptor, alpha Protein, Il6r Protein, IL6R Protein, Il6ra Protein

Hintergrund:

Background: Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

Synonym: Interleukin-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6R 1, Membrane glycoprotein 80, gp80, CD126

Molekulargewicht: 38.9 kDa

UniProt: P22272

Pathways: JAK-STAT Signalweg, Autophagie, Growth Factor Binding, Cancer Immune Checkpoints