IL-6 Protein (AA 29-212)

Produktnummer ABIN2018139

Recombinant IL-6-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für IL-6 Protein (AA 29-212) (ABIN2018139)

Target: IL-6 (IL6) (Interleukin 6 (IL6))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % by SDS-PAGE analysis.

Produktdetails

Proteineigenschaft: AA 29-212

Produktmerkmale: ED50 <0.1 ng/mL, measured by the dose-dependent stimulation of the proliferation of IL-6 dependent murine 7TD1 cells, corresponding to a specific activity of > 1 x 10^7 units/mg.
AA 29-212, expressed with an N-terminal Met.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against 1xPBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant human Interleukin-6 (rhIL-6) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhIL-6 should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: IL-6 (IL6) (Interleukin 6 (IL6))

Andere Bezeichnung: Interleukin-6 (IL-6)

Hintergrund: Interleukin-6 (IL-6, also known as IFN-beta2) is a pleiotropic cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 is secreted by T cells and macrophages to stimulate immune response. IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow. It supports the growth of B cells and is antagonistic to regulatory T cells.Recombinant human Interleukin-6 (rhIL-6) produced in E. coli is a single non-glycosylated polypeptide chain containing 185 amino acids. A fully biologically active molecule, rhIL-6 has a molecular mass of 20.9 kDa analyzed by reducing SDS-PAGE.
Synonyms: 26 kDa protein, IFN-beta2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2

Molekulargewicht: 20.9 kDa, observed by reducing SDS-PAGE.

UniProt: Q75MH2

Pathways: TLR Signalweg, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagie, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome