IL12 Protein (AA 23-215, AA 23-335)

Produktnummer ABIN2018058

Produktdetails

Target: IL12 (Interleukin 12 (IL12))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 23-215, AA 23-335

Spezies: Maus

Quelle: CHO Cells

Produktmerkmale: ED50 < 0.15 ng/mL, measured in a cell proliferation assay using 2D6 cells.
AA 23-215 (p35) and AA 23-335 (p40), expressed with C-terminal 6xHis.

Reinheit: > 95 % as analyzed by SDS-PAGE.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant murineInterleukin-12 (IL-12), remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, murine Interleukin-12 (IL-12), His should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: IL12 (Interleukin 12 (IL12))

Andere Bezeichnung: Interleukin-12 (IL-12) (IL12 Produkte)

Synonyme: CLMF Protein, CLMF2 Protein, IL-12B Protein, NKSF Protein, NKSF2 Protein, p40 Protein, Il-12b Protein, Il12p40 Protein, Il-12p40 Protein, Il12 Protein, IL-12p40 Protein, IL-12 Protein, LOC100217488 Protein, IL-12p35 Protein, Il-12a Protein, Ll12a Protein, p35 Protein, IL12p40 Protein, IL12B Protein, IL-12 p35 Protein, interleukin 12B Protein, interleukin 12A Protein, interleukin 12b Protein, interleukin 12a Protein, Interleukin 12 level Protein, IL12B Protein, IL12A Protein, Il12b Protein, Il12a Protein, IL12 Protein, il12a Protein

Hintergrund: Interleukin-12 (IL-12), also known as NKSF, TCMF, CLMF and TSF, is a heterodimeric cytokine composed of p35 and p40 subunits. It is produced by monocytes, macrophages, B cells and dendritic cells in response to bacterial lipopolysaccharides and intracellular pathogens. IL-12 signals throughtheIL-12 receptor complex, which is comprised of IL-12 Rbeta1 and IL-12 Rbeta2. IL-12 induces the proliferation and activation of hematopoietic stem cells, natural killer cells and T- cells. It is indispensible during the development of Th1 cells, leading to the production of IFN-gamma and IL-2.
Synonyms: NKSF, TCMF, CLMF, TSF

Molekulargewicht: 27-29 kDa (p35) and 45-50 kDa (p40), observed by reducing SDS-PAGE.

UniProt: P43431, P43432

Pathways: JAK-STAT Signalweg, TLR Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome