Huntington's disease (HD) is the most common inherited neurodegenerative disease and is characterized by uncontrolled excessive motor movements and cognitive and emotional deficits.(1) Although the early stages of motor symptoms are hyperkinetic, in later stages of the disease, motor symptoms tend to be hypokinetic with bradykinesia and dystonia. Other classic symptoms are motor impersistence and abnormal eye movements. Late in the disease, dysphagia becomes a symptom with high morbid impact, as aspiration is a common occurrence, and pneumonia is a common cause of death.(2)
Here you will find a list of hand-picked antibodies, reagents, kits, and other tools you need for your research in the field of Huntington's, as well as some resources on this important topic.
The following targets are directly related to research on Huntington's disease. Click on the links to find relevant products we offer.
The huntingtin protein is required for human development and normal brain function. It is subject to posttranslational modification, and some events, such as phosphorylation, can play an enormous role in regulating toxicity of the huntingtin protein.(3)
Below you will find our best-selling HTT antibodies with human and mouse reactivity. Click on a link to see available PubMed references, images and more product details.
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(1) Finkbeiner S. Huntington's Disease. Cold Spring Harb Perspect Biol. 2011 Jun 1;3(6):a007476. doi: 10.1101/cshperspect.a007476. PMID: 21441583; PMCID: PMC3098678.
(2) Nopoulos PC. Huntington disease: a single-gene degenerative disorder of the striatum. Dialogues Clin Neurosci. 2016 Mar;18(1):91-8. PMID: 27069383; PMCID: PMC4826775.
(3) Zheng Z, Diamond MI. Huntington disease and the huntingtin protein. Prog Mol Biol Transl Sci. 2012;107:189-214. doi: 10.1016/B978-0-12-385883-2.00010-2.