Telefon:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antikoerper-online.de

SARS-CoV-2 Mutations Research Tools Tracker

Stay up to date re mutation specific antibodies, proteins, assays

As the pandemic continues, SARS-CoV-2 variants continue to increase. This page helps to keep track of virus lineages and mutation specific products.

SARS-CoV-2 Lineages of Concern
SARS-CoV-2 Lineages of Note
UPDATE

CR3022 not affected by B.1.1.7, B.1.251 and P.1 Mutations!

SARS-CoV-2 Lineages

Fig. 1: Amino acid changes in the spike region of the genomes mapped to the spike protein sequences structure. Comparison of Mutations in the viral spike identified in B.1.351 / 501Y.V2 (SA), B.1.1.7 (UK) A.23.1 (UG) and P.1 (BR). RBD region is highlighted (orange).

B.1.1.7 Lineage

Background B.1.1.7: Initially a UK lineage, associated with a variant of concern with N501Y, P681H and numerous other mutations. Evidence of having higher transmissibility than other lineage resulting in rapid growth in the UK and internationally.1

Mutations: N501Y, A570D, D614G, P681H, T716I ,S982A, D1118H, D3L (N protein), S235F (N protein), T1001I (orf1ab), A1708D (orf1ab), 2230T (orf1a), Q27 (orf8)

Proteins:

Produkt
Source
Kat. Nr.
Menge
Lieferzeit
SourceHEK-293 Cells
Kat. Nr.ABIN6963742
Menge100 μg
Lieferzeit6 bis 7 Tage
SourceHEK-293 Cells
Kat. Nr.ABIN6971314
Menge100 μg
Lieferzeit5 Days

Multiplex ELISAs:

Produkt
Kat. Nr.
Menge
Lieferzeit
Kat. Nr.ABIN6972933
Menge96 tests
Lieferzeit7 bis 8 Tage
Kat. Nr.ABIN6972931
Menge96 tests
Lieferzeit7 bis 8 Tage
Kat. Nr.ABIN6972932
Menge96 tests
Lieferzeit7 bis 8 Tage

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251 and P.1 Mutations! Click to see detailed data.

Produkt
Klonalität
Clone
Isotype
Source
Kat. Nr.
Validierungen
Menge
KlonalitätMonoclonal
CloneCR3022
IsotypeIgG1 kappa
SourceHuman
Kat. Nr.ABIN6952546
Validierungen
  • (8)
  • collections(9)
Menge200 μg
KlonalitätChimeric
CloneCR3022
IsotypeIgG kappa
SourceRabbit
Kat. Nr.ABIN6952547
Validierungen
  • (7)
  • collections(3)
Menge200 μg
KlonalitätMonoclonal
Clone
IsotypeIgG1
SourceMouse
Kat. Nr.ABIN6953169
Validierungen
Menge1 mg
KlonalitätChimeric
CloneAM122
IsotypeIgG1
SourceHuman
Kat. Nr.ABIN6953206
Validierungen
  • collections(5)
Menge100 μg

References:

  • Pengfei Wang, Lihong Liu, Sho Iketani, Yang Luo et al. Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization. bioRxiv preprint posted January 26, 2021. ; https://doi.org/10.1101/2021.01.25.428137doi.
  • Reuschl, A.-K., Thome, L. G., Zuliani-Alvarez, L., et al. Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant. bioRxiv preprint posted January 24, 2021. ; https://dx.doi.org/10.1101%2F2021.01.24.427991.
  • Xiaoying Shen, Haili Tang, Charlene McDanal, et al. SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines. https://doi.org/10.1016/j.chom.2021.03.002.
  • Wilfredo F. Garcia-Beltran, Evan C. Lam, Kerri St. Denis, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Published: March 12, 2021. DOI:https://doi.org/10.1016/j.cell.2021.03.013

B.1.351 Lineage

Background B.1.351: A lineage first identified in South Africa and defined by new variant of concern 501Y.V2

Mutations: K417N, A570D, D614G, P681H, T716I, S982A, D1118H, L18F, D215G, K417K, E484K, N501Y, A701V, P71L (E protein), T205I (N protein), K1655N (orf1a)

Proteins:

Produkt
Source
Kat. Nr.
Menge
Lieferzeit
SourceHEK-293 Cells
Kat. Nr.ABIN6963740
Menge100 μg
Lieferzeit6 bis 7 Tage

Multiplex ELISAs:

Produkt
Kat. Nr.
Menge
Lieferzeit
Kat. Nr.ABIN6972933
Menge96 tests
Lieferzeit7 bis 8 Tage
Kat. Nr.ABIN6972931
Menge96 tests
Lieferzeit7 bis 8 Tage
Kat. Nr.ABIN6972932
Menge96 tests
Lieferzeit7 bis 8 Tage

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251 and P.1 Mutations! Click to see detailed data.

Produkt
Klonalität
Clone
Isotype
Source
Kat. Nr.
Validierungen
Menge
KlonalitätMonoclonal
CloneCR3022
IsotypeIgG1 kappa
SourceHuman
Kat. Nr.ABIN6952546
Validierungen
  • (8)
  • collections(9)
Menge200 μg
KlonalitätChimeric
CloneCR3022
IsotypeIgG kappa
SourceRabbit
Kat. Nr.ABIN6952547
Validierungen
  • (7)
  • collections(3)
Menge200 μg
KlonalitätMonoclonal
Clone
IsotypeIgG1
SourceMouse
Kat. Nr.ABIN6953169
Validierungen
Menge1 mg
KlonalitätChimeric
CloneAM122
IsotypeIgG1
SourceHuman
Kat. Nr.ABIN6953206
Validierungen
  • collections(5)
Menge100 μg

References:

  • Pengfei Wang, Lihong Liu, Sho Iketani, Yang Luo et al. Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization. bioRxiv preprint posted January 26, 2021. ; https://doi.org/10.1101/2021.01.25.428137doi.
  • Mary Hongying Cheng, James M Krieger, Burak Kaynak, et al. Impact of South African 501.V2 Variant on SARS-CoV-2 Spike Infectivity and Neutralization: A Structure-based Computational Assessment. doi: https://doi.org/10.1101/2021.01.10.426143.
  • Hoffmann, M., Arora, P., Groß, R., et al. SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies. To appear in Cell. DOI: https://doi.org/10.1016/j.cell.2021.03.036.
  • Venkata Viswanadh Edara, Carson Norwood, Katharine Floyd, et al. Infection and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant. Cell Host & Microbe, Mar 21, 2021. https://doi.org/10.1016/j.chom.2021.03.009.
  • Wilfredo F. Garcia-Beltran, Evan C. Lam, Kerri St. Denis, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Published: March 12, 2021. DOI:https://doi.org/10.1016/j.cell.2021.03.013

B.1.429 Lineage

Background B.1.429: A lineage predominantly circulating in California but with exports to other countries.1

Mutations: L452R, W152C, D5584Y (orf1ab), T205I (N protein)

Proteins:

Produkt
Source
Kat. Nr.
Menge
Lieferzeit
SourceHEK-293 Cells
Kat. Nr.ABIN6972926
Menge100 μg
Lieferzeit6 bis 7 Tage

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251 and P.1 Mutations! Click to see detailed data.

Produkt
Klonalität
Clone
Isotype
Source
Kat. Nr.
Validierungen
Menge
KlonalitätMonoclonal
CloneCR3022
IsotypeIgG1 kappa
SourceHuman
Kat. Nr.ABIN6952546
Validierungen
  • (8)
  • collections(9)
Menge200 μg
KlonalitätChimeric
CloneCR3022
IsotypeIgG kappa
SourceRabbit
Kat. Nr.ABIN6952547
Validierungen
  • (7)
  • collections(3)
Menge200 μg
KlonalitätChimeric
CloneAM122
IsotypeIgG1
SourceHuman
Kat. Nr.ABIN6953206
Validierungen
  • collections(5)
Menge100 μg

References:

  • Wilfredo F. Garcia-Beltran, Evan C. Lam, Kerri St. Denis, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Published: March 12, 2021. DOI:https://doi.org/10.1016/j.cell.2021.03.013

P.1 Lineage

Background P.1: A lineage first identified in Brazil with variants of biological significance E484K, N501Y and K417T, described in a recent virological post: here. P.1 lineage is an alias of lineage B.1.1.28.1.1

Mutations: V1176F, L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, P80R (N protein), G174C (orf3a), E92K (orf8)

Proteins:

Produkt
Source
Kat. Nr.
Menge
Lieferzeit
SourceHEK-293 Cells
Kat. Nr.ABIN6964443
Menge100 μg
Lieferzeit6 bis 7 Tage

Antibodies:

Chimeric MAb ABIN6953206 is a chimeric monoclonal antibody combining the constant domains of the human IgG1 Molecule with mouse variable regions. CR3022 antibody ABIN6952546 not affected by B.1.1.7, B.1.251 and P.1 Mutations! Click to see detailed data.

Produkt
Klonalität
Clone
Isotype
Source
Kat. Nr.
Validierungen
Menge
KlonalitätMonoclonal
CloneCR3022
IsotypeIgG1 kappa
SourceHuman
Kat. Nr.ABIN6952546
Validierungen
  • (8)
  • collections(9)
Menge200 μg
KlonalitätChimeric
CloneCR3022
IsotypeIgG kappa
SourceRabbit
Kat. Nr.ABIN6952547
Validierungen
  • (7)
  • collections(3)
Menge200 μg
KlonalitätMonoclonal
Clone
IsotypeIgG1
SourceMouse
Kat. Nr.ABIN6953169
Validierungen
Menge1 mg
KlonalitätChimeric
CloneAM122
IsotypeIgG1
SourceHuman
Kat. Nr.ABIN6953206
Validierungen
  • collections(5)
Menge100 μg

References:

  • Toovey OTR, Harvey KN, Bird PW, Tang JWW. Introduction of Brazilian SARS-CoV-2 484K.V2 related variants into the UK [published online ahead of print, 2021 Feb 3]. J Infect. 2021;S0163-4453(21)00047-5. doi:10.1016/j.jinf.2021.01.025
  • Wilfredo F. G.-B., Evan C. Lam, Kerri St. D., Adam D. N. Circulating SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. doi: https://doi.org/10.1101/2021.02.14.21251704.
  • Hoffmann, M., Arora, P., Groß, R., et al. SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies. To appear in Cell. DOI: https://doi.org/10.1016/j.cell.2021.03.036.
  • Wilfredo F. Garcia-Beltran, Evan C. Lam, Kerri St. Denis, et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Published: March 12, 2021. DOI:https://doi.org/10.1016/j.cell.2021.03.013

B.1.526 Lineage

Background B.1.526: The variant that Ho’s team identified in New York, also known as B.1.526, carries a notorious mutation called E484K that has been found in variants identified in South Africa and Brazil. Studies by multiple labs have shown that the E484K change — which is in a portion of the coronavirus spike protein that recognizes host cells — weakens the potency of antibodies that can ordinarily disable the virus.7

Mutations: T95I, D253G, L5F, D253G, E484K, D614G, A701V with a smaller fraction having S477N instead of E484K.1

Proteins:

- Products under development. Get in touch! -

References:

  • Annavajhala, M. K., Mohri, H., Zucker, J. E., et al. A Novel SARS-CoV-2 Variant of Concern, B.1.526, Identified in New York. doi: https://doi.org/10.1101/2021.02.23.21252259.

A.23.1 Lineage

Background A.23.1: International lineage with variants of biological significance F157L, V367F, Q613H and P681R, described fully in the preprent: Bugembe et al 2021. Q613H is predicted to be functionally equivalent to the D614G mutation that arose early in 2020.1

Mutations: F157L, V367F, Q613H and P681R

Proteins:

- Products under development. Get in touch! -

References:

  • Bugembe, D. L., Phan, My V.T., Ssewanyana, I., et al. A SARS-CoV-2 lineage A variant (A.23.1) with altered spike has emerged and is dominating the current Uganda epidemic. medRxiv 2021.02.08.21251393; doi: https://doi.org/10.1101/2021.02.08.21251393

B.1.525 Lineage

Background B.1.525: International lineage with variants of biological significance E484K, Q677H, F888L and a similar suite of deletions to B.1.1.7.1

Mutations: E484K, Q677H, F888L and a similar suite of deletions to B.1.1.7., Q52R, L21F (E protein), I82T (E protein), L471F (orf1ab)1

Proteins:

Produkt
Source
Kat. Nr.
Menge
Lieferzeit
SourceHEK-293 Cells
Kat. Nr.ABIN6972924
Menge100 μg
Lieferzeit6 bis 7 Tage

CR3022 antibodies: bind to epitope residues in the RBD that are not mutated2,3,4,5

Produkt
Klonalität
Clone
Isotype
Source
Kat. Nr.
Validierungen
Menge
KlonalitätMonoclonal
CloneCR3022
IsotypeIgG1 kappa
SourceHuman
Kat. Nr.ABIN6952546
Validierungen
  • (8)
  • collections(9)
Menge200 μg
KlonalitätChimeric
CloneCR3022
IsotypeIgG kappa
SourceRabbit
Kat. Nr.ABIN6952547
Validierungen
  • (7)
  • collections(3)
Menge200 μg

References:

B.1.2 Lineage

Background B.1.2: Independent genomic surveillance programs based in New Mexico and Louisiana contemporaneously detected the rapid rise of numerous clade 20G (lineage B.1.2) infections carrying a Q677P substitution in S. The variant was first detected in the US on October 23, yet between 01 Dec 2020 and 19 Jan 2021 it rose to represent 27.8% and 11.3% of all SARS-CoV-2 genomes sequenced from Louisiana and New Mexico, respectively.6

Mutations: Q677P

Proteins:

- Products under development. Get in touch! -

References:

  • Hodcroft, E. B., Domman, D. B., Snyder, D. J. Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677. medRxiv preprint on February 14, 2021. doi: https://doi.org/10.1101/2021.02.12.21251658

Wild Type Protein

We offer a high quality recombinant SARS-CoV-2 wild type protein. Click on the link to find more details.

Produkt
Source
Kat. Nr.
Menge
Lieferzeit
SourceHEK-293 Cells
Kat. Nr.ABIN6952670
Menge100 μg
Lieferzeit6 bis 7 Tage

B.1.617 Lineage

Background B.1.617: A new and potentially concerning variant first identified in India late last year, known as B.1.617, has become dominant in the state of Maharashtra. B.1.617 has drawn attention because it contains two mutations that have been linked to increased transmissibility and an ability to evade immune protection. It has now been detected in 20 other countries.8

Mutations: E484Q, L452R

Proteins:

Produkt
Source
Kat. Nr.
Menge
Lieferzeit
SourceHEK-293 Cells
Kat. Nr.ABIN6976302
Menge100 μg
Lieferzeit30 bis 35 Tage

References:

CR3022 not affected by B.1.1.7, B.1.251 and P.1 Mutations

One of the looming questions regarding newly emerging variants of SARS-CoV-2 such as the variants of concern B.1.1.7, B.1.351, and P.1. is, whether existing antibody based assays and pharmaceuticals remain useable. In collaboration with Nanotemper we measured the affinity of our S protein RBD antibody CR3022 (ABIN6952546) to the canonical trimeric SARS-CoV-2 S protein and those of the variants of concern B.1.1.7, B.1.351, and P.1. by microscale thermophoresis (MST). These measurements will be extended to additional antibodies and protein variants in the near future.

Click here for more detailed data and information regarding CR3022!

References

  • (1) https://cov-lineages.org/global_report.html
  • (2) Barnes CO et al. SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies. Nature (2020). doi:10.1038/s41586-020-2852-1
  • (3) Cheng MH et al. Impact of South African 501.V2 Variant on SARS-CoV-2 Spike Infectivity and Neutralization: A Structure-based Computational Assessment. bioRxiv 2021.01.10.426143 (2021). doi:10.1101/2021.01.10.426143
  • (4) Garcia-Beltran WF et al. Circulating SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. medRxiv 2021.02.14.21251704 (2021). doi:10.1101/2021.02.14.21251704
  • (5) Yuan M et al. A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV. Science 368, 630–633 (2020).
  • (6) Hodcroft, E. B., Domman, D. B., Snyder, D. J. Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677. medRxiv preprint on February 14, 2021. doi: https://doi.org/10.1101/2021.02.12.21251658
  • (7) https://www.nature.com/articles/d41586-021-00564-4
  • (8) https://www.nature.com/articles/d41586-021-01059-y
Sie sind hier:
help Kundenservice