Bcl-2 Antikörper

Produktnummer ABIN968975

Der Maus Monoklonal Anti-Bcl-2-Antikörper wurde für IHC, FACS, ELISA und ICC validiert. Er ist geeignet, Bcl-2 in Proben von Human und Maus zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für Bcl-2 Antikörper (ABIN968975)

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Bcl-2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC)

Klon: 8E12

Produktdetails anti-Bcl-2 Antikörper

Verwendungszweck: BCL-2 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Synthetic peptide corresponding to residues surrounding BCL-2, conjugated to KLH.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-Bcl-2 Antikörper (ABIN968975)

Choi, Feng, Yoon: "FKBP38 protects Bcl-2 from caspase-dependent degradation." in: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 9770-9, (2010) (PubMed).

Munda, Hajdinjak, Kavalar, Stiblar Martincic: "p53, Bcl-2 and AgNOR tissue markers: model approach in predicting prostate cancer characteristics." in: The Journal of international medical research, Vol. 37, Issue 6, pp. 1868-76, (2010) (PubMed).

Murphy, Green, Adams, Squire, Kuo, McKay: "Pharmacogenomics in the curricula of colleges and schools of pharmacy in the United States." in: American journal of pharmaceutical education, Vol. 74, Issue 1, pp. 7, (2010) (PubMed).

Details zu Bcl-2

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Andere Bezeichnung: BCL-2

Hintergrund: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma.Tissue specificity: Expressed in a variety of tissues.

Molekulargewicht: 26 kDa

Gen-ID: 596

UniProt: P10415

Pathways: MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagie, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling