JNK Antikörper (pThr183)
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- Target Alle JNK (MAPK8) Antikörper anzeigen
- JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))
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Bindungsspezifität
- pThr183
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser JNK Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Flow Cytometry (FACS)
- Kreuzreaktivität
- Maus, Ratte (Rattus)
- Produktmerkmale
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Aufreinigung
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Phosphorylated Human JNK/SAPK (pT183/pY185) Peptide
- Klon
- 41-JNK-SAPK
- Isotyp
- IgG1
- Top Product
- Discover our top product MAPK8 Primärantikörper
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- Kommentare
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Related Products: ABIN968535, ABIN968632, ABIN967389, ABIN968074
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store undiluted at -20°C.
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Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7." in: The Biochemical journal, Vol. 352 Pt 1, Issue 3, pp. 145-54, (2001) (PubMed).
: "Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation." in: Physiological reviews, Vol. 81, Issue 2, pp. 807-69, (2001) (PubMed).
: "The hem of the garment." in: Seminars in dialysis, Vol. 14, Issue 1, pp. 76, (2001) (PubMed).
: "p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system." in: Neuron, Vol. 14, Issue 1, pp. 67-78, (1995) (PubMed).
: "Monoclonal antibodies react with neuronal subpopulations in the human nervous system." in: The Journal of comparative neurology, Vol. 267, Issue 3, pp. 398-408, (1988) (PubMed).
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Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7." in: The Biochemical journal, Vol. 352 Pt 1, Issue 3, pp. 145-54, (2001) (PubMed).
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- Target
- JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))
- Andere Bezeichnung
- JNK (MAPK8 Produkte)
- Synonyme
- JNK antikoerper, JNK-46 antikoerper, JNK1 antikoerper, JNK1A2 antikoerper, JNK21B1/2 antikoerper, PRKM8 antikoerper, SAPK1 antikoerper, SAPK1c antikoerper, AI849689 antikoerper, Prkm8 antikoerper, BSK antikoerper, BSK/DJNK antikoerper, Bsk antikoerper, CG5680 antikoerper, D-JNK antikoerper, D-junk antikoerper, DBSK/JNK antikoerper, DJNK antikoerper, DJNK/bsk antikoerper, Dmel\\CG5680 antikoerper, JNK/SAPK antikoerper, Jnk antikoerper, Junk antikoerper, SAPKa antikoerper, c-Jun antikoerper, dJNK antikoerper, jnk antikoerper, T10F20.15 antikoerper, jnk1 antikoerper, sapk1 antikoerper, mapk8 antikoerper, zgc:112379 antikoerper, JNKb antikoerper, mapk8b antikoerper, mitogen-activated protein kinase 8 antikoerper, Stress-activated protein kinase jnk-1 antikoerper, basket antikoerper, Protein kinase superfamily protein antikoerper, mitogen-activated protein kinase 8 L homeolog antikoerper, mitogen-activated protein kinase 8b antikoerper, mitogen-activated protein kinase 8B-like antikoerper, MAPK8 antikoerper, jnk-1 antikoerper, Mapk8 antikoerper, bsk antikoerper, ATMPK8 antikoerper, mapk8.L antikoerper, mapk8b antikoerper, LOC109094263 antikoerper
- Hintergrund
- The Ras signaling pathway links the signals from growth factor receptors with the activation of the MAPK kinase cascade of phosphorylation leading to cell growth and differentiation. External stimuli, like endotoxins, UV irradiation, heat, and hyperosmolarity, induce an array of cellular responses that culminate with gene expression, ultimately dictating an adaptation to the new environment. Small GTPases of the Rho family, including cdc42, Rac1, and Rho, transmit the stress signals that initiate the signal cascade. JNK is a c-Jun kinase that was also identified as SAPK1 and MAPKp49. JNK/SAPK, along with p38 and RK5/BMK1, comprise three classes of stress-activated MAPK groups. Complete activation of JNK/SAPK requires the phosphorylation of both Thr183 and Tyr185, which are located in a Thr-X-Tyr motif. The activation of these residues is believed to be carried out by MKK4 and MKK7. Active JNK/SAPK phosphorylates other kinases and multiple transcription factors that induce expression of genes, such as proinflammatory cytokines.
- Molekulargewicht
- 43 & 56 kDa
- Pathways
- MAPK Signalweg, WNT Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, S100 Proteine
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