p53 Antikörper (Tumor Protein P53) (AA 195-393)

Details for Product anti-TP53 Antibody No. ABIN967802, Anbieter: Anmelden zum Anzeigen
Antigen
  • BCC7
  • LFS1
  • P53
  • TRP53
  • p53
  • Trp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • tp53
  • Xp53
  • TP53
  • tumor protein p53
  • cellular tumor antigen p53
  • transformation related protein 53
  • tumor protein p53 L homeolog
  • TP53
  • CpipJ_CPIJ002758
  • Tp53
  • tp53
  • Trp53
  • tp53.L
Epitop
AA 195-393
171
122
84
79
71
69
66
57
55
51
48
47
47
43
41
35
33
31
25
22
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17
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1
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1
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1
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Reaktivität
Hund, Human
2325
504
426
182
119
93
83
83
33
23
20
20
20
16
15
14
6
4
4
4
3
3
3
2
1
1
Wirt
Maus
1332
1104
7
1
1
1
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser p53 Antikörper ist unkonjugiert
82
77
64
52
46
45
45
31
31
26
25
25
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14
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14
14
12
7
5
5
5
5
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5
5
5
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2
2
2
Applikation
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
1876
834
755
738
623
605
410
340
306
179
72
41
32
30
21
17
17
15
13
9
9
4
4
3
3
3
2
1
1
1
1
1
1
1
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Monkey p53 aa. 195-393
Klon 80-p53
Isotyp IgG2b, kappa
Kreuzreaktivität Human, Hund
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Andere Bezeichnung p53 (TP53 Antibody Abstract)
Hintergrund The p53 protein is critical to regulation of normal cell growth and is a suppressor of tumor cell proliferation. Inactivation of p53 by a number of mechanisms, such as missense mutations or interaction with oncogenic viral or cellular proteins, can result in tumor progression. Mutations and/or allelic loss of the p53 gene is associated with a wide variety of human tumors. Known to have a role in transcriptional regulation, p53 suppresses various promoters containing TATA elements in an apparently sequence-independent fashion. p53 also binds to DNA in a sequence-specific manner via recognition of a 20 bp consensus-binding site. This interaction stimulates the expression of genes downstream of the p53 binding site. A number of genes that contain p53-binding sites have been identified, including MDM2, GADD45, and muscle creatine kinase. It is thought that MDM2 is a feedback regulator of p53. In addition, a p53-inducible gene, Cip1, has been identified and shown to suppress tumor cell growth in culture.
Molekulargewicht 53 kDa
Pathways p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store undiluted at -20°C.
Bilder des Herstellers
Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) (AA 195-393) antibody (ABIN967802) Western blot analysis of p53 on A431 lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1...
 image for anti-Tumor Protein P53 (TP53) (AA 195-393) antibody (ABIN967802) A431
Produkt verwendet in: Saitoh, Pizzi, Wang: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, 2002 (PubMed).

Stahnke, Fulda, Friesen, Strauss, Debatin: "Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy." in: Blood, Vol. 98, Issue 10, pp. 3066-73, 2001 (PubMed).

Natsugoe, Nakashima, Matsumoto, Xiangming, Okumura, Kijima, Ishigami, Takebayashi, Baba, Takao, Aikou: "Expression of p21WAF1/Cip1 in the p53-dependent pathway is related to prognosis in patients with advanced esophageal carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 5, Issue 9, pp. 2445-9, 1999 (PubMed).

Hurd, Khattree, Alban, Nag, Jhanwar, Dinda, Moudgil: "Hormonal regulation of the p53 tumor suppressor protein in T47D human breast carcinoma cell line." in: The Journal of biological chemistry, Vol. 270, Issue 48, pp. 28507-10, 1996 (PubMed).

Mercer: "Cell cycle regulation and the p53 tumor suppressor protein." in: Critical reviews in eukaryotic gene expression, Vol. 2, Issue 3, pp. 251-63, 1992 (PubMed).

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