MAPK10 Antikörper

Produktnummer ABIN966522

Zitiert in 6+ Publikationen. Der Monoklonal anti-MAPK10 Antikörper (ABIN966522) detektiert spezifisch MAPK10 in WB, ELISA und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MAPK10 Antikörper (ABIN966522)

Target: MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser MAPK10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-MAPK10 Antikörper

Spezifität: Ni-NTA purified truncated recombinant MAPK10 expressed in E. Coli strain BL21 (DE3)

Aufreinigung: Antibodies are purified by protein A affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 500- 1: 1,000
IHC(P): 1: 500- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Referenzen für anti-MAPK10 Antikörper (ABIN966522)

Irving, Bamford: "Role of mitogen- and stress-activated kinases in ischemic injury." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 22, Issue 6, pp. 631-47, (2002) (PubMed).

Cuenda: "Mitogen-activated protein kinase kinase 4 (MKK4)." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, (2000) (PubMed).

Kuan, Yang, Samanta Roy, Davis, Rakic, Flavell: "The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development." in: Neuron, Vol. 22, Issue 4, pp. 667-76, (1999) (PubMed).

Gupta, Barrett, Whitmarsh, Cavanagh, Sluss, Dérijard, Davis: "Selective interaction of JNK protein kinase isoforms with transcription factors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2760-70, (1996) (PubMed).

Martin, Mohit, Miller: "Developmental expression in the mouse nervous system of the p493F12 SAP kinase." in: Brain research. Molecular brain research, Vol. 35, Issue 1-2, pp. 47-57, (1996) (PubMed).

Forsgren, Moravec, Moravec: "Catecholamine-synthesizing enzymes and neuropeptides in rat heart epicardial ganglia; an immunohistochemical study." in: The Histochemical journal, Vol. 22, Issue 12, pp. 667-76, (1991) (PubMed).

Details zu MAPK10

Target: MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))

Andere Bezeichnung: MAPK10

Hintergrund: MAPK10 (mitogen-activated protein kinase 10 ), also called JNK3, which is located on chromosome 4q22.1q23, JNK is an important contributor to stress-induced apoptosis, its isoforms (JNK1, JNK2, and JNK3) have distinct roles in cerebral ischemia. JNK1 is the major isoformresponsible for the high level of basal JNK activity in the brain. In contrast, targeted deletion of Jnk3 not only reduces the stress-induced JNK activity, but also protects mice from brain injury after cerebral ischemiahypoxia. The downstream mechanism of JNK3-mediated apoptosis include the induction of Bim and Fas and the mitochondrial release of cytochrome c. which suggest that JNK3 is a potential target for neuroprotection therapies in stroke. JNK3 is crucial for neuronal apoptosis (stress-induced) and selectively expressed in the nervous system and heart.

Gen-ID: 5602

Pathways: MAPK Signalweg, WNT Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades