p53 Antikörper

Produktnummer ABIN866051

Der Kaninchen-Polyklonal Anti-p53-Antikörper wurde für WB validiert. Er ist geeignet zum Nachweis von p53 in Proben aus Human. }

Kurzübersicht für p53 Antikörper (ABIN866051)

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p53 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-p53 Antikörper

Spezifität: This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of N-terminal residues of p53.

Kreuzreaktivität: Human, Maus

Produktmerkmale: Positive Control: A431. Cellular Localization: Cytoplasm, nucleus

Aufreinigung: Immunogen affinity purified

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5mg/ml

Buffer: 1xTBS (pH7.4), 0.5% BSA, 25% Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu p53

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Andere Bezeichnung: p53

Hintergrund: P53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. It acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. P53 is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. p53 is frequently mutated or inactivated in about 60% of cancers

Molekulargewicht: ~70kDa

UniProt: Q91XH8

Pathways: p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt