GTPase NRas Antikörper

Produktnummer ABIN7938430

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GTPase NRas in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für GTPase NRas Antikörper (ABIN7938430)

Target: GTPase NRas (NRAS)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GTPase NRas Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GTPase NRas Antikörper

Verwendungszweck: NRAS antibody (pAb), sample

Aufreinigung: Protein A Chromatography

Immunogen: This information is proprietary to Active Motif and/or its suppliers.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: *WB: 1 - 4 μg/mL dilution *For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.05 % Tween 20 to all blocking solutions may also reduce background. Individual optimization may be required.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu GTPase NRas

Target: GTPase NRas (NRAS)

Andere Bezeichnung: NRAS

Hintergrund:

Background_Plain: Oncogenic mutations in Ras genes have been found in about 30 % of human cancers. This family of genes is involved in cell signaling pathways that control cell growth and death. The human Ras gene family consists of three identified members H-, K- and N-ras encoding proteins of 188-189 amino acids and 21,000 (p21) daltons. Human H- and K-ras are the homologues of v-H- and v-K-ras, sequences. Under normal circumstances the Ras-GTPase activity gradually converts GTP to GDP, but in oncogenic mutations Ras locks the protein into the active GTP conformation. This leads to a constant Ras gene and uncontrollable cell growth. Through signal transduction, NRAS is involved in regulating cells division. The information is received from outside the cell to the cell's nucleus to instruct the cell to proliferate, to mature or to differentiate. Due to these intracellular relationship Ras antibodies have emerged as a valuable tool for target validation studies for cancer.

Aliases: Neuroblastoma RAS Viral Oncogene Homolog, nras, Nras, NRAS

Molekulargewicht: 21 kDa

NCBI Accession: NP_002515

Pathways: p53 Signalweg, MAPK Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling