LRP6 Antikörper (pSer1490)
Kurzübersicht für LRP6 Antikörper (pSer1490) (ABIN743558)
Target
Alle LRP6 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
- 
    - 
                                            Bindungsspezifität
- pSer1490
- 
                                            Kreuzreaktivität
- Human, Maus, Ratte
- 
                                            Homologie
- Dog,Cow,Pig,Horse,Chicken
- 
                                            Aufreinigung
- Purified by Protein A.
- 
                                            Immunogen
- KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490
- 
                                            Isotyp
- IgG
 
- 
                                            
- 
    
- 
    - 
                                            Applikationshinweise
- 
                        WB 1:300-5000
 ELISA 1:500-1000
 IHC-P 1:200-400
 IHC-F 1:100-500
 IF(IHC-P) 1:50-200
 IF(IHC-F) 1:50-200
 IF(ICC) 1:50-200
- 
                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
- 
                                            
- 
    - 
                                            Format
- Liquid
- 
                                            Konzentration
- 1 μg/μL
- 
                                            Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 
                                            Konservierungsmittel
- ProClin
- 
                                            Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 
                                            Lagerung
- 4 °C,-20 °C
- 
                                            Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 
                                            Haltbarkeit
- 12 months
 
- 
                                            
- 
    - 
                                            : "FGF2 crosstalk with Wnt signaling in mediating the anabolic action of PTH on bone formation."    in: Bone reports, Vol. 9, pp. 136-144, (2018)         (PubMed).        
 : "Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 96, Issue 2, pp. 249-59, (2016) (PubMed).
 : "Urotensin II inhibited the proliferation of cardiac side population cells in mice during pressure overload by JNK-LRP6 signalling." in: Journal of cellular and molecular medicine, Vol. 18, Issue 5, pp. 852-62, (2014) (PubMed).
 
 
- 
                                            : "FGF2 crosstalk with Wnt signaling in mediating the anabolic action of PTH on bone formation."    in: Bone reports, Vol. 9, pp. 136-144, (2018)         (PubMed).        
- 
    - LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
- 
                                            Andere Bezeichnung
- LRP6
- 
                                            Hintergrund
- 
                        Synonyms: ADCAD2, Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6 Background: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). 
- 
                                            Gen-ID
- 4040
- 
                                            UniProt
- O75581
- 
                                            Pathways
- WNT Signalweg, Tube Formation
 Target
- 
                    
 
                                     
                                     
                                    