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LRP6 Antikörper (pSer1490)

Der Kaninchen Polyklonal Anti-LRP6-Antikörper wurde für WB, ELISA, IF (p), IF (cc), IHC (p) und IHC (fro) validiert. Er ist geeignet, LRP6 in Proben von Human, Maus und Ratte zu detektieren. Es sind 3+ Publikationen verfügbar.
Produktnummer ABIN743558

Kurzübersicht für LRP6 Antikörper (pSer1490) (ABIN743558)

Target

Alle LRP6 Antikörper anzeigen
LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Reaktivität

  • 76
  • 47
  • 23
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 66
  • 10
  • 1
  • 1
Kaninchen

Klonalität

  • 65
  • 13
Polyklonal

Konjugat

  • 29
  • 5
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser LRP6 Antikörper ist unkonjugiert

Applikation

  • 60
  • 26
  • 25
  • 25
  • 18
  • 18
  • 12
  • 12
  • 7
  • 5
  • 3
  • 2
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 22
    • 21
    • 8
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer1490

    Kreuzreaktivität

    Human, Maus, Ratte

    Homologie

    Dog,Cow,Pig,Horse,Chicken

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Xiao, Fei, Hurley: "FGF2 crosstalk with Wnt signaling in mediating the anabolic action of PTH on bone formation." in: Bone reports, Vol. 9, pp. 136-144, (2018) (PubMed).

    Boone, Arend, Johnston, Cooper, Gilchrist, Oelschlager, Grizzle, McGwin, Gangrade, Straughn, Buchsbaum: "Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 96, Issue 2, pp. 249-59, (2016) (PubMed).

    Chen, Xu, Ye, Li, Gong, Zhang, Wu, Jia, Liu, Chen, Yang, Tang, Zhu, Ge, Zou: "Urotensin II inhibited the proliferation of cardiac side population cells in mice during pressure overload by JNK-LRP6 signalling." in: Journal of cellular and molecular medicine, Vol. 18, Issue 5, pp. 852-62, (2014) (PubMed).

  • Target

    LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

    Andere Bezeichnung

    LRP6

    Hintergrund

    Synonyms: ADCAD2, Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6

    Background: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

    Gen-ID

    4040

    UniProt

    O75581

    Pathways

    WNT Signalweg, Tube Formation
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