LRP6 Antikörper (AA 1531-1560)
Kurzübersicht für LRP6 Antikörper (AA 1531-1560) (ABIN3028807)
Target
Alle LRP6 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 1531-1560
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Verwendungszweck
- LRP6 Antibody
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Aufreinigung
- Purified
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Immunogen
- A portion of amino acids 1531-1560 from the human protein was used as the immunogen for this LRP6 antibody.
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Isotyp
- Ig Fraction
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Applikationshinweise
- Titration of the LRP6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the LRP6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
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Andere Bezeichnung
- LRP6
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Hintergrund
- LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
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UniProt
- O75581
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Pathways
- WNT Signalweg, Tube Formation
Target
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