LRP6 Antikörper (AA 1198-1370)

Produktnummer ABIN7193277

Der Maus Monoklonal anti-LRP6 Antikörper (Klon 1A3F5) (ABIN7193277) detektiert spezifisch LRP6 in ELISA und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für LRP6 Antikörper (AA 1198-1370) (ABIN7193277)

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LRP6 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Klon: 1A3F5

Produktdetails anti-LRP6 Antikörper

Bindungsspezifität: AA 1198-1370

Verwendungszweck: LRP6 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human LRP6 (AA: 1198-1370) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Details zu LRP6

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Andere Bezeichnung: LRP6

Hintergrund:

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Molekulargewicht: 180 kDa

UniProt: O75581

Pathways: WNT Signalweg, Tube Formation