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LRP6 Antikörper (C-Term)

LRP6 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB01837 unconjugated
Produktnummer ABIN390100
  • Target Alle LRP6 Antikörper anzeigen
    LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
    Bindungsspezifität
    • 17
    • 16
    • 9
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1531-1560, C-Term
    Reaktivität
    • 63
    • 37
    • 18
    • 2
    • 2
    Human
    Wirt
    • 60
    • 3
    • 1
    • 1
    Kaninchen
    Klonalität
    • 62
    • 3
    Polyklonal
    Konjugat
    • 25
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser LRP6 Antikörper ist unkonjugiert
    Applikation
    • 59
    • 27
    • 26
    • 26
    • 22
    • 17
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1560 amino acids from the C-terminal region of human LRP6.
    Klon
    RB01837
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product LRP6 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Ye, Go, Singh, Liu, Keramati, Mani: "LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake." in: The Journal of biological chemistry, Vol. 287, Issue 2, pp. 1335-44, (2012) (PubMed).

    Keramati, Singh, Lin, Faramarzi, Ye, Mane, Tellides, Lifton, Mani: "Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 5, pp. 1914-8, (2011) (PubMed).

    Liu, Prior, Piwnica-Worms, Bu: "LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 11, pp. 5136-41, (2010) (PubMed).

  • Target
    LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
    Andere Bezeichnung
    LRP6 (LRP6 Produkte)
    Synonyme
    lrp6-A antikoerper, Xlrp6 antikoerper, adcad2 antikoerper, lrp6 antikoerper, LRP6 antikoerper, ADCAD2 antikoerper, C030016K15Rik antikoerper, Cd antikoerper, Gw antikoerper, LDL receptor related protein 6 antikoerper, LDL receptor related protein 6 L homeolog antikoerper, LDL receptor related protein 6 S homeolog antikoerper, low density lipoprotein receptor-related protein 6 antikoerper, low-density lipoprotein receptor-related protein 6 antikoerper, LRP6 antikoerper, lrp6.L antikoerper, lrp6.S antikoerper, lrp6 antikoerper, Lrp6 antikoerper, LOC590395 antikoerper
    Hintergrund
    LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
    Molekulargewicht
    180429
    Gen-ID
    4040
    NCBI Accession
    NP_002327
    UniProt
    O75581
    Pathways
    WNT Signalweg, Tube Formation
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