Bcl-2 Antikörper (AA 1-200)

Produktnummer ABIN7858364

Dieser Maus Monoklonal Antikörper detektiert spezifisch Bcl-2 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Bcl-2 Antikörper (AA 1-200) (ABIN7858364)

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Bcl-2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: BCL2-6915

Produktdetails anti-Bcl-2 Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody

Spezifität: This antibody recognizes a protein of 25-26 kDa, identified as the bcl-279 79oΩ 79oΩlpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-279 79oΩ 79oΩlpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-279 79oΩ 79oΩlpha protein, whereas the normal or hyperplastic germinal centers are negative.Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human BCL2 protein (exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu Bcl-2

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Andere Bezeichnung: Bcl-2

Hintergrund:

Apoptosis regulator Bcl-2, B-cell CLL/lymphoma-2

HL-60|Jurkat|K562|or HeLa cells. Tonsil or follicular lymphomas.

Molekulargewicht: 25-26kDa

Gen-ID: 596, 150749

Pathways: MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagie, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling