IL12 Antikörper

Produktnummer ABIN7670659

Dieses Anti-IL12-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IL12 in ELISA. Geeignet für Ratte.

Kurzübersicht für IL12 Antikörper (ABIN7670659)

Target: IL12 (Interleukin 12 (IL12))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL12 Antikörper ist unkonjugiert

Applikation: ELISA

Produktdetails anti-IL12 Antikörper

Verwendungszweck: IL-12 p70 Polyclonal Antibody(Capture/Detector)

Aufreinigung: Antigen Affinity Purification

Immunogen: Recombinant Rat IL-12 p70 protein expressed by Mammalian

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Konservierungsmittel: Without preservative

Handhabung: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Haltbarkeit: 12 months

Details zu IL12

Target: IL12 (Interleukin 12 (IL12))

Andere Bezeichnung: IL-12 p70

Hintergrund: IL-12A,IL12a,InterLeukin-12 subunit aLpha,Cytotoxic Lymphocyte maturation factor 35 kDa subunit (CLMF p35),IL-12 subunit p35,IL12b,IL12B,InterLeukin-12 subunit beta,Cytotoxic Lymphocyte maturation factor 40 kDa subunit,IL-12 subunit p40,Heterodimerizes with Il12B to form the Il-12 cytokine or with EBI3/Il27B to form the Il-35 cytokine. Il-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses,induces the production of interferon-gamma (IFN-gamma),favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically,exerts its biological effects through a receptor composed of Il12R1 and Il12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn,recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes.As part of Il-35,plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine.Mediates biological events through unconventional receptors composed of Il12RB2 and gp130/Il6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4,which form a unique heterodimer that binds to distinct DNA sites.

UniProt: Q9R103, Q9R278

Pathways: JAK-STAT Signalweg, TLR Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome