IL12 Antikörper (Biotin)

Produktnummer ABIN6963864

Produktdetails anti-IL12 Antikörper (Biotin)

Target: IL12 (Interleukin 12 (IL12))

Reaktivität: Human, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL12 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, ELISpot

Spezifität: IL-12 (p70)

Kreuzreaktivität (Details): The monoclonal antibody cross-reacts with IL-12 (p70) from non-human primates.

Produktmerkmale: This monoclonal antibody enables specific detection of human IL-12 (p70) in immunoassays such as ELISpot, FluoroSpot, and ELISA. Serum/Plasma samples

Aufreinigung: Biotinylated through reaction with a N-hydroxysuccinimide ester of biotin.,Purified from in vitro cultures by protein G affinity chromatography.

Sterilität: 0.2 μm filtered

Immunogen: Recombinant human IL-12 p70

Klon: MT704

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

ABIN6963864 and ABIN7448307 is recommended as detection mAb in ELISpot, FluoroSpot, and ELISA in combination with capture mAbs .

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: supplied at 0.5 mg/mL in PBS with 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Haltbarkeit: 18 months

Referenzen für anti-IL12 Antikörper (Biotin) (ABIN6963864)

Tomasicchio, Semple, Esmail, Meldau, Randall, Pooran, Davids, Cairncross, Anderson, Downs, Malherbe, Novitzky, Panieri, Oelofse, Londt, Naiker, Dheda: "An autologous dendritic cell vaccine polarizes a Th-1 response which is tumoricidal to patient-derived breast cancer cells." in: Cancer immunology, immunotherapy : CII, Vol. 68, Issue 1, pp. 71-83, (2019) (PubMed).

Tootoonchian, Pak, Ardekani, Sehati, Abedi-Valugerdi, Kokhaei: "Evaluation of interleukin 12 and CD56+ lymphocyte cells in pediatric hematopoietic stem cell transplantation for early diagnosis of acute graft versus host disease." in: Transplant immunology, Vol. 39, pp. 25-29, (2018) (PubMed).

Tagawa, Albanese, Bouvet, Moosmann, Mautner, Heissmeyer, Zielinski, Lutter, Hoser, Hastreiter, Hayes, Sugden, Hammerschmidt: "Epstein-Barr viral miRNAs inhibit antiviral CD4+ T cell responses targeting IL-12 and peptide processing." in: The Journal of experimental medicine, Vol. 213, Issue 10, pp. 2065-80, (2017) (PubMed).

Zhang, Morgan, Beane, Zheng, Dudley, Kassim, Nahvi, Ngo, Sherry, Phan, Hughes, Kammula, Feldman, Toomey, Kerkar, Restifo, Yang, Rosenberg: "Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 21, Issue 10, pp. 2278-88, (2016) (PubMed).

Persson, Ekerfelt, Jablonowska, Jonsson, Ernerudh, Jenmalm, Berg: "Immunological status in patients undergoing in vitro fertilisation: responses to hormone treatment and relationship to outcome." in: Journal of reproductive immunology, Vol. 96, Issue 1-2, pp. 58-67, (2013) (PubMed).

Details zu IL12

Target: IL12 (Interleukin 12 (IL12))

Andere Bezeichnung: IL12 (p70) (IL12 Produkte)

Synonyme: CLMF antikoerper, CLMF2 antikoerper, IL-12B antikoerper, NKSF antikoerper, NKSF2 antikoerper, p40 antikoerper, Il-12b antikoerper, Il12p40 antikoerper, Il-12p40 antikoerper, Il12 antikoerper, IL-12p40 antikoerper, IL-12 antikoerper, LOC100217488 antikoerper, IL-12p35 antikoerper, Il-12a antikoerper, Ll12a antikoerper, p35 antikoerper, IL12p40 antikoerper, IL12B antikoerper, IL-12 p35 antikoerper, interleukin 12B antikoerper, interleukin 12A antikoerper, interleukin 12b antikoerper, interleukin 12a antikoerper, Interleukin 12 level antikoerper, IL12B antikoerper, IL12A antikoerper, Il12b antikoerper, Il12a antikoerper, IL12 antikoerper, il12a antikoerper

Gen-ID: 3592, 3593

Pathways: JAK-STAT Signalweg, TLR Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome