p53 Antikörper (AA 50-100)
Kurzübersicht für p53 Antikörper (AA 50-100) (ABIN7448707)
Target
Alle p53 (TP53) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 50-100
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Verwendungszweck
- Rabbit anti-p53 IHC Antibody, Affinity Purified
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Homologie
- Gorilla,Chimpanzee,Common tree shrew
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Aufreinigung
- Affinity Purified
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Immunogen
- Between AA 50 and 100
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Isotyp
- IgG
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Applikationshinweise
- 1:100 - 1:500
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 100 μg/mL
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Buffer
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- p53 (TP53) (Tumor Protein P53 (TP53))
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Andere Bezeichnung
- p53
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Hintergrund
- Background: p53 is a tumor suppressor protein that is mutated or inactivated in over 50 % of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis.
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Gen-ID
- 7157
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NCBI Accession
- NP_000537
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UniProt
- P04637
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Pathways
- p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt
Target
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