p53 Antikörper (AA 1-391)

Produktnummer ABIN7178833

Dieses Anti-p53-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von p53 in WB und ELISA. Geeignet für Ratte.

Kurzübersicht für p53 Antikörper (AA 1-391) (ABIN7178833)

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p53 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-p53 Antikörper

Bindungsspezifität: AA 1-391

Kreuzreaktivität: Maus, Ratte

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Rat Cellular tumor antigen p53 protein (1-391AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu p53

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Andere Bezeichnung: Tp53

Hintergrund:

Background: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression By similarity. Interacts with GRK5

Aliases: Tp53 antibody, P53 antibody, Cellular tumor antigen p53 antibody, Tumor suppressor p53 antibody

UniProt: P10361

Pathways: p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt