TRAF6 Antikörper (AA 1-522)

Produktnummer ABIN7172247

Der Kaninchen Polyklonal Anti-TRAF6-Antikörper wurde für IHC, ELISA und IF validiert. Er ist geeignet, TRAF6 in Proben von Human zu detektieren.

Kurzübersicht für TRAF6 Antikörper (AA 1-522) (ABIN7172247)

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRAF6 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-TRAF6 Antikörper

Bindungsspezifität: AA 1-522

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human TNF receptor-associated factor 6 protein (1-522AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TRAF6

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Andere Bezeichnung: TRAF6

Hintergrund:

Background: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of \\\'Lys-63\\\'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Aliases: E3 ubiquitin-protein ligase TRAF6 antibody, Interleukin 1 signal transducer antibody, Interleukin-1 signal transducer antibody, MGC 3310 antibody, MGC:3310 antibody, MGC3310 antibody, OTTHUMP00000232772 antibody, OTTHUMP00000232773 antibody, RING finger protein 85 antibody, RNF 85 antibody, RNF85 antibody, TNF receptor associated factor 6 antibody, TNF receptor-associated factor 6 antibody, TNF receptor-associated factor 6, E3 ubiquitin protein ligase antibody, TRAF 6 antibody, Traf6 antibody, TRAF6_HUMAN antibody

UniProt: Q9Y4K3

Pathways: NF-kappaB Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway