RIPK1 Antikörper (AA 328-458) (Biotin)

Produktnummer ABIN7167471

Der Kaninchen Polyklonal Anti-RIPK1-Antikörper wurde für ELISA validiert. Er ist geeignet, RIPK1 in Proben von Human zu detektieren.

Kurzübersicht für RIPK1 Antikörper (AA 328-458) (Biotin) (ABIN7167471)

Target: RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIPK1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Produktdetails anti-RIPK1 Antikörper (Biotin)

Bindungsspezifität: AA 328-458

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 protein (328-458AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RIPK1

Target: RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))

Andere Bezeichnung: RIPK1

Hintergrund:

Background: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at \'Ser-728\' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via \'Lys-63\'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

Aliases: Cell death protein RIP antibody, FLJ39204 antibody, OTTHUMP00000039163 antibody, Receptor (TNFRSF) interacting serine threonine kinase 1 antibody, receptor interacting protein 1 antibody, Receptor interacting protein antibody, Receptor interacting protein kinase 1 antibody, Receptor interacting serine threonine protein kinase 1 antibody, Receptor TNFRSF interacting serine threonine kinase 1 antibody, Receptor-interacting protein 1 antibody, Receptor-interacting serine/threonine-protein kinase 1 antibody, Rinp antibody, RIP 1 antibody, RIP antibody, Rip-1 antibody, RIP1 antibody, RIPK 1 antibody, Ripk1 antibody, RIPK1_HUMAN antibody, Serine threonine protein kinase RIP antibody, Serine/threonine-protein kinase RIP antibody

UniProt: Q13546

Pathways: NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom, Ubiquitin Proteasome Pathway