PDK2 Antikörper (AA 128-407)

Produktnummer ABIN7142006

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PDK2 in WB, IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PDK2 Antikörper (AA 128-407) (ABIN7142006)

Target: PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-PDK2 Antikörper

Bindungsspezifität: AA 128-407

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial protein (128-407AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PDK2

Target: PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2))

Andere Bezeichnung: PDK2

Hintergrund:

Background: Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.

Aliases: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2 antibody, mitochondrial antibody, PDHK2 antibody, PDK2 antibody, PDK2_HUMAN antibody, Pyruvate dehydrogenase kinase isoform 2 antibody, Pyruvate dehydrogenase kinase, isozyme 2 antibody, Pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial antibody

UniProt: Q15119

Pathways: PI3K-Akt Signalweg, RTK Signalweg, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effekt