TRAF6 Antikörper

Produktnummer ABIN6655371

Hersteller Produkt- Nr.: 200-401-i32

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TRAF6 in WB und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TRAF6 Antikörper (ABIN6655371)

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRAF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-TRAF6 Antikörper

Hersteller Produkt- Nr.: 200-401-i32

Hersteller: Rockland

Verwendungszweck: TRAF6 Antibody

Kreuzreaktivität (Details): A BLAST analysis was used to suggest cross-reactivity with Anti-TRAF6 from human and mouse based on 100 % homology with the immunizing sequence.

Aufreinigung: Anti-TRAF6 Antibody was purified by Protein G chromatography.

Immunogen: TRAF6 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to an internal amino acid sequence in the human protein TRAF6.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optional[Neutralization_Dilution]: 3-5 μg/mL

Kommentare:

Anti-TRAF6 Antibody is tested for use in WB and FLOW. Expect a band approximately 54kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 0.05 % BSA

Preservative: 0.05 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu TRAF6

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Andere Bezeichnung: TRAF6

Hintergrund:

Synonyms: RNF85, NF receptor-associated factor 6, E3 ubiquitin-protein ligase TRAF6, Interleukin-1 signal transducer, RING finger protein 85

Background: Anti-TRAF6 Antibody detects human TRAF6. Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). Recently it has been shown that TRANCE/OPGL activates the antiapoptotic serine/threonine kinase Akt/PKB through a signaling complex involving c-Src and TRAF6. Mice deficient in TNF receptor-associated factor 6 (TRAF6) are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function. Like TRAF2 and TRAF3, TRAF6 is also essential for perinatal and postnatal survival. These findings establish unexpectedly diverse and critical roles for TRAF6 in perinatal and postnatal survival, bone metabolism, LPS, and cytokine signaling. RANK (TRANCE receptor) interacts with various TRAFs through distinct motifs and activates NF-kB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kB activation. Over-expression of TRAF6 activates JNK, p38, or IKK in the absence of extracellular stimulation. Anti-TRAF6 Antibody is ideal for investigators involved in Toll Like Receptors and signaling, cyotkines, growth factors and AKT Singaling.

Gene Name: TRAF6

Gen-ID: 7189

NCBI Accession: NP_004611

UniProt: Q9Y4K3

Pathways: NF-kappaB Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway