p21 Protein Antikörper

Details zu Produkt Nr. ABIN6567150
Target
Reaktivität
Human, Maus, Ratte
78
31
25
4
4
4
4
2
Wirt
Kaninchen
70
11
Klonalität
Polyklonal
Konjugat
Unkonjugiert
6
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (IHC)
47
46
38
26
13
13
12
12
10
6
1
1
Optionen
Immunogen Recombinant protein of human CDKN1A
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung p21
Hintergrund

Synonyms: CAP20,CDK-interacting protein 1,CDKI,CDKN1,Cdkn1a,CDN1A,CIP1,Cyclin Dependent Kinase Inhibitor 1A,Cyclin-dependent kinase inhibitor 1,Cyclin-dependent kinase inhibitor 1A (P21),Cyclin-dependent kinase inhibitor 1A (p21,Cip1),DNA Synthesis Inhibitor,MDA-6,MDA6,Melanoma differentiation-associated protein 6,Melanoma differentiation-associated protein,p21,P21 protein,p21CIP1,p21Cip1/Waf1,p21WAF,PIC1,SDI1,SLC12A9,WAF1,Wild type p53 activated fragment 1 (WAF1),Wild type p53 activated fragment 1,Wildtype p53-activated fragment 1

Background: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

Molekulargewicht

Calculated_MW: 18kDa

Gen-ID 1026
UniProt P38936
Applikations-hinweise IHC 1:50 - 1:200 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-p21 Protein antibody (ABIN6567150) Immunohistochemistry of paraffin-embedded mouse liver using CDKN1A Antibody.
Image no. 2 for anti-p21 Protein antibody (ABIN6567150) Immunofluorescence analysis of MCF-7 cells using CDKN1A antibody.