p21 Produkte
(Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
Kategorien
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010].
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Ausgewählte p21 Kategorien
p21 Antikörper
High quality antibodies with extensive validation data.
p21 ELISA Kits
Reliable ELISA kits for a wide range of species.
p21 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene p21 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (3)
- (7)
Kat. Nr.
ABIN3022006
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
IHC, IF
Validierungen
- (6)
Kat. Nr.
ABIN7255634
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF, PLA
Validierungen
- (2)
- (5)
Kat. Nr.
ABIN560309
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene p21 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966175
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Cow
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6966176
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6955163
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene p21 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122536
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122535
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1349005
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren p21 Produkten
: "Evidence that SARS-CoV-2 Induces Lung-Cell Senescence: Potential Impact on COVID-19 Lung Disease." in: American journal of respiratory cell and molecular biology, (2021) (PubMed).: "Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A." in: Molecular medicine reports, Vol. 22, Issue 5, pp. 3873-3885, (2021) (PubMed).
: "p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence." in: Matrix biology : journal of the International Society for Matrix Biology, (2019) (PubMed).
: "Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells." in: Cell biology and toxicology, (2019) (PubMed).
: "Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells." in: Experimental cell research, Vol. 370, Issue 2, pp. 292-302, (2018) (PubMed).
: "LncRNA GACAT3 acts as a competing endogenous RNA of HMGA1 and alleviates cucurbitacin B-induced apoptosis of gastric cancer cells." in: Gene, (2018) (PubMed).
: "Dicer1 downregulation by multiple myeloma cells promotes the senescence and tumor-supporting capacity and decreases the differentiation potential of mesenchymal stem cells." in: Cell death & disease, Vol. 9, Issue 5, pp. 512, (2018) (PubMed).
: "Cullin3/KCTD5 induces monoubiquitination of ΔNp63α and impairs its activity." in: FEBS letters, Vol. 592, Issue 13, pp. 2334-2340, (2018) (PubMed).
: "Radiation-induced premature cellular senescence involved in glomerular diseases in rats." in: Scientific reports, Vol. 8, Issue 1, pp. 16812, (2018) (PubMed).
: "DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 7, pp. E1224-E1233, (2017) (PubMed).
Synonyme und alternative Namen zu p21
cyclin D1 (CCND1), cyclin dependent kinase inhibitor 1A (CDKN1A), cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a), cyclin-dependent kinase inhibitor 1A (Cdkn1a), cyclin-dependent kinase inhibitor 1A L homeolog (cdkn1a.L), cyclin-dependent kinase inhibitor 1 (cki1), cyclin-dependent kinase inhibitor 1A (cdkn1a), cyclin dependent kinase inhibitor 1A (Cdkn1a), KRAS proto-oncogene, GTPase (KRAS), CAP20, cap20, CCND1, CDKI, CDKN1, Cdkn1, cdkn1, CDKN1A, CIP1, Cip1, cip1, KRAS2, MDA-6, mda-6, mda6, p16Xic2, P21, p21, p21CIP1, p21Cip1, p21cip1, p21ras, p21WAF, SDI1, sdi1, si:ch1073-48m5.2, UV96, WAF1, Waf1, waf1Bezeichner auf Proteinebene für p21
- cyclin D1
- cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- CDK-interacting protein 1
- CDK-interaction protein 1
- DNA synthesis inhibitor
- cyclin-dependent kinase inhibitor 1
- melanoma differentiation associated protein 6
- wild-type p53-activated fragment 1
- melanoma differentiation-associated protein
- p21
- cyclin-dependent kinase inhibitor 1A (P21)
- cyclin dependent kinase inhibitor p16Xic2
- cip1
- p21
- waf1
- cyclin-dependent kinase inhibitor 1A
- p21/WAF1
- GTPase KRas
- Kirsten rat sarcoma viral (Kras-2) oncogene homolog
- v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
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