Insulin Antikörper

Produktnummer ABIN6297591

Dieses Anti-Insulin-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Insulin in IHC. Geeignet für Human, Schwein, Maus, Rind (Kuh) und Ratte.

Kurzübersicht für Insulin Antikörper (ABIN6297591)

Target: Insulin (INS)

Reaktivität: Human, Schwein, Maus, Rind (Kuh), Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Insulin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-Insulin Antikörper

Verwendungszweck: Mouse anti-Human/Cow Pig/Mouse/Rat Insulin Antibody [IHC only]

Spezifität: Cytoplasmic

Aufreinigung: Recombinant INS protein was used as the immunogen for the Insulin antibody.

Immunogen: Recombinant INS protein was used as the immunogen for the Insulin antibody.

Anwendungsinformationen

Applikationshinweise: Prediluted format : incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu Insulin

Target: Insulin (INS)

Andere Bezeichnung: Insulin

Hintergrund:

Target Description: Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.

Gene Symbol: INS

Gen-ID: 3630

UniProt: P01308

Pathways: NF-kappaB Signalweg, RTK Signalweg, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagie, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation