p53 Antikörper

Produktnummer ABIN6297587

Der Maus Monoklonal Anti-p53-Antikörper wurde für IHC validiert. Er ist geeignet, p53 in Proben von Human, Affe und Rind (Kuh) zu detektieren.

Kurzübersicht für p53 Antikörper (ABIN6297587)

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Reaktivität: Human, Affe, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser p53 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-p53 Antikörper

Verwendungszweck: Mouse anti-Human/Monkey/Cow p53 Antibody Cocktail [IHC only]

Spezifität: Nuclear

Aufreinigung: Recombinant human wild-type p53 protein (BP53-12) & Recombinant human wild type p53 protein expressed in E. coli (DO-7) were used as the immunogen for this antibody cocktail.

Immunogen: Recombinant human wild-type p53 protein (BP53-12) & Recombinant human wild type p53 protein expressed in E. coli (DO-7) were used as the immunogen for this antibody cocktail.

Anwendungsinformationen

Applikationshinweise: Prediluted format : incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu p53

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Andere Bezeichnung: Cellular tumor antigen p53

Hintergrund:

Target Description: This antibody cocktail is specific for a 53 kDa protein, which is identified as p53 suppressor gene product. The antibody cocktail reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. antibody to p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Gene Symbol: TP53///P53

Gen-ID: 7157

UniProt: P04637

Pathways: p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt