MAP3K1 Antikörper (AA 1211-1310)

Produktnummer ABIN6294295

Dieser Maus Monoklonal Antikörper detektiert spezifisch MAP3K1 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für MAP3K1 Antikörper (AA 1211-1310) (ABIN6294295)

Target: MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAP3K1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-MAP3K1 Antikörper

Bindungsspezifität: AA 1211-1310

Verwendungszweck: Mouse anti-Human MAP3K1 Antibody [IHC only]

Spezifität: Cytoplasmic

Aufreinigung: A partial recombinant protein (aa 1211-1310) was used as the immunogen for the MAP3K1 antibody.

Immunogen: A partial recombinant protein (aa 1211-1310) was used as the immunogen for the MAP3K1 antibody.

Anwendungsinformationen

Applikationshinweise: Prediluted format : incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu MAP3K1

Target: MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1))

Andere Bezeichnung: Mitogen-activated protein kinase kinase kinase 1

Hintergrund:

Target Description: Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli, including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NF-kB pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination.

Gene Symbol: MAP3K1///MAPKKK1///MEKK///MEKK1

Gen-ID: 4214

UniProt: Q13233

Pathways: MAPK Signalweg, Interferon-gamma Pathway, Caspase Kaskade in der Apoptose, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Regulation of Actin Filament Polymerization, Toll-Like Receptors Cascades