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LRP6 Antikörper (C-Term)

This anti-LRP6 antibody (ABIN6263009) is a Rabbit Polyclonal antibody detecting LRP6 in WB, IHC, ELISA. Suitable for Human, Mouse, Rat.
Produktnummer ABIN6263009

Kurzübersicht für LRP6 Antikörper (C-Term) (ABIN6263009)

Target

Alle LRP6 Antikörper anzeigen
LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Reaktivität

  • 76
  • 47
  • 23
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 66
  • 10
  • 1
  • 1
Kaninchen

Klonalität

  • 65
  • 13
Polyklonal

Konjugat

  • 29
  • 5
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser LRP6 Antikörper ist unkonjugiert

Applikation

  • 60
  • 27
  • 26
  • 24
  • 18
  • 18
  • 12
  • 12
  • 8
  • 6
  • 3
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • Bindungsspezifität

    • 22
    • 22
    • 8
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    LRP6 Antibody detects endogenous levels of total LRP6.

    Homologie

    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human LRP6, corresponding to a region within C-terminal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Zhu, Wang, Zhao, Zhang, Wu, Wang, Hu: "Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma." in: Oncotarget, Vol. 8, Issue 14, pp. 22825-22834, (2017) (PubMed).

  • Target

    LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

    Andere Bezeichnung

    LRP6

    Hintergrund

    Description: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

    Gene: LRP6

    Molekulargewicht

    180 kDa

    Gen-ID

    4040

    UniProt

    O75581

    Pathways

    WNT Signalweg, Tube Formation
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