LRP6 Antikörper (C-Term)
Kurzübersicht für LRP6 Antikörper (C-Term) (ABIN6263009)
Target
Alle LRP6 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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    - 
                                            Bindungsspezifität
- C-Term
- 
                                            Spezifität
- LRP6 Antibody detects endogenous levels of total LRP6.
- 
                                            Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- 
                                            Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 
                                            Immunogen
- A synthesized peptide derived from human LRP6, corresponding to a region within C-terminal amino acids.
- 
                                            Isotyp
- IgG
 
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- 
    - 
                                            Applikationshinweise
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- 
                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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- 
    - 
                                            Format
- Liquid
- 
                                            Konzentration
- 1 mg/mL
- 
                                            Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 
                                            Konservierungsmittel
- Sodium azide
- 
                                            Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 
                                            Lagerung
- -20 °C
- 
                                            Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- 
                                            Haltbarkeit
- 12 months
 
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- 
    - 
                                            : "Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma."    in: Oncotarget, Vol. 8, Issue 14, pp. 22825-22834, (2017)         (PubMed).        
 
 
- 
                                            : "Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma."    in: Oncotarget, Vol. 8, Issue 14, pp. 22825-22834, (2017)         (PubMed).        
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    - LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))
- 
                                            Andere Bezeichnung
- LRP6
- 
                                            Hintergrund
- 
                        Description: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). Gene: LRP6 
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                                            Molekulargewicht
- 180 kDa
- 
                                            Gen-ID
- 4040
- 
                                            UniProt
- O75581
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                                            Pathways
- WNT Signalweg, Tube Formation
 Target
- 
                    
 
                                     
                                     
                                    