p53 Antikörper (AA 1-100)

Produktnummer ABIN6149405

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch p53 in WB, IHC und IP. Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für p53 Antikörper (AA 1-100) (ABIN6149405)

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p53 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-p53 Antikörper

Bindungsspezifität: AA 1-100

Sequenz: EPPEAGSEYT TIHYKYMCNS SCMGGMNRRP ILTIITLEDS SGNLLGRDSF EVRVCACPGR DRRTEEENFR KKEVLCPELP PGSAKRALPT CTSASPPQKK KPLDGEYFTL KIRGRKRFEM FRELNEALEL KDAHATEESG DSRAHSSYLK TKKGQSTSRH KKTMVKKVGP DSD

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human p53 (NP_000537.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:3000 - 1:6000,IHC,1:50 - 1:200,IP,1:20 - 1:50

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-p53 Antikörper (ABIN6149405)

Huang, Cui, Chen, Yang, Lian, Liu, Su, Liu, Wang, Hu, Ouyang, Li, Lu: "NVP-BEZ235 synergizes cisplatin sensitivity in osteosarcoma." in: Oncotarget, Vol. 9, Issue 12, pp. 10483-10496, (2018) (PubMed).

Huang, Zhou, He, Ke, Wen, Zou, Chen: "Hyperthermia enhances 17-DMAG efficacy in hepatocellular carcinoma cells with aggravated DNA damage and impaired G2/M transition." in: Scientific reports, Vol. 6, pp. 38072, (2018) (PubMed).

Zhang, Cui, Wang, Zhao, Hou, Zeng, Zhang, Yu, Zhao, Nie, Chen, Wang, Liu: "Autophagy regulates high concentrations of iodide-induced apoptosis in SH-SY5Y cells." in: Toxicology letters, Vol. 284, pp. 129-135, (2018) (PubMed).

Meng, Song, Wang, Li, Liu, Cui: "Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer cell line MDA-MB-231." in: Oncology reports, Vol. 37, Issue 2, pp. 841-848, (2017) (PubMed).

Cai, Huang, Luo, Yang, Zhang, Liu, Lin, Xie, Wang: "Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine." in: Cell death & disease, Vol. 7, pp. e2161, (2016) (PubMed).

Details zu p53

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Andere Bezeichnung: TP53

Hintergrund: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).,BCC7,LFS1,P53,TRP53,p53,TP53,BMFS5,Epigenetics & Nuclear Signaling,Transcription Factors,DNA Damage & Repair,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,PI3K-Akt Signaling Pathway,ErbB-HER Signaling Pathway,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Cell Cycle,Cell cycle inhibitors,G1/S Checkpoint,G2/M DNA Damage Checkpoint,Endocrine & Metabolism,AMPK Signaling Pathway,Warburg Effect,Neuroscience,Neurodegenerative Diseases,TP53

Molekulargewicht: 43 kDa

Gen-ID: 7157

UniProt: P04637

Pathways: p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt