p53 Antikörper (Ser46)

Produktnummer ABIN5957023

Der Kaninchen Polyklonal anti-p53 Antikörper (ABIN5957023) detektiert spezifisch p53 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Affe.

Kurzübersicht für p53 Antikörper (Ser46) (ABIN5957023)

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Reaktivität: Human, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p53 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-p53 Antikörper

Bindungsspezifität: Ser46

Spezifität: Antigen NY-CO-13,BCC7,Cellular tumor antigen p53,FLJ92943,LFS1,Mutant tumor protein 53,p53,p53 tumor suppressor,P53,Phosphoprotein p53,Tp53,Transformation related protein 53,TRP53,Tumor protein 53,Tumor protein p53,Tumor suppressor p53

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human p53 around the non-phosphorylation site of Ser46.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, ELISA 1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu p53

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Andere Bezeichnung: p53

Hintergrund: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Molekulargewicht: 44kDa

Gen-ID: 7157

UniProt: P04637

Pathways: p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt