Parkin Antikörper (pSer101)

Produktnummer ABIN5688885

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Parkin in WB. Er zeigt eine Reaktivität gegenüber Human und Rind (Kuh).

Kurzübersicht für Parkin Antikörper (pSer101) (ABIN5688885)

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Reaktivität: Human, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Parkin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Parkin Antikörper

Bindungsspezifität: pSer101

Aufreinigung: Affinity Purified

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser101 of human parkin.

Anwendungsinformationen

Applikationshinweise: The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will react with bovine and non-human primate tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Parkin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Details zu Parkin

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Andere Bezeichnung: Parkin

Hintergrund: Parkin is an E3 ligase in the ubiquitin-proteasome system. Hereditary Parkinson's disease is most commonly caused by mutations in the parkin gene and is characterized by the progressive loss of dopaminergic neurons and the presence of Lewy bodies in the substania nigra (Jenner aet al.,1992). Recent evidence suggests that phosphorylation of parkin at Ser101 may have an important regulatory role on its E3 ubiquitin ligase activity (Yamamoto et al., 2005).

Molekulargewicht: 52 kDa

Gen-ID: 5071

UniProt: O60260

Pathways: Autophagie, Ubiquitin Proteasome Pathway