IL-1 beta Antikörper (N-Term)

Produktnummer ABIN5326748

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch IL-1 beta in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Kaninchen, Hund und Pferd. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für IL-1 beta Antikörper (N-Term) (ABIN5326748)

Target: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Reaktivität: Human, Maus, Kaninchen, Hund, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-1 beta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-IL-1 beta Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: IL1B Antibody - N-terminal region

Sequenz: MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL

Homologie: Dog: 92%, Horse: 86%, Human: 100%, Mouse: 75%, Rabbit: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against IL1B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human IL1B

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54323-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-IL-1 beta Antikörper (ABIN5326748)

Lee, Lu, Chai, Sheu, Chen, Huang, Kao, Chen, Chung, Sung, Chang, Lee, Yip: "Circulating microparticles enhanced rat vascular wall remodeling following endothelial denudation." in: American journal of translational research, Vol. 8, Issue 11, pp. 4511-4522, (2016) (PubMed).

Wang, Jiang, Li, He, Zhao, Yang, Zhu, Yin, Li, Wang, Liu, Shang, Yang, Wang, Zhen, Zhang, Yu, Zhong, Ye, Huang, Yuan: "Shigella flexneri T3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-?B p65 protein." in: Cellular microbiology, Vol. 15, Issue 3, pp. 474-85, (2013) (PubMed).

Details zu IL-1 beta

Target: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Andere Bezeichnung: IL1B

Hintergrund:

Background Information: IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. The gene encoding IL1B and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Gene Name: Interleukin 1, beta

Alternative Symbols: IL-1, IL1F2, IL1beta, IL1-BETA

Protein Name: Interleukin-1 beta

Molekulargewicht: 17

Gen-ID: 3553

NCBI Accession: NP_000567

UniProt: P01584

Pathways: NF-kappaB Signalweg, Interferon-gamma Pathway, TLR Signalweg, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagie, Cancer Immune Checkpoints, Inflammasome