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IL-1 beta Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IL-1 beta in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Kaninchen, Hund und Pferd und wurde in 2+ Publikationen erwähnt.
Produktnummer ABIN5326748

Kurzübersicht für IL-1 beta Antikörper (N-Term) (ABIN5326748)

Target

Alle IL-1 beta (IL1B) Antikörper anzeigen
IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Reaktivität

  • 164
  • 117
  • 77
  • 33
  • 29
  • 25
  • 18
  • 17
  • 11
  • 11
  • 8
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
Human, Maus, Kaninchen, Hund, Pferd

Wirt

  • 221
  • 136
  • 8
  • 8
  • 4
  • 3
  • 3
  • 2
  • 2
Kaninchen

Klonalität

  • 229
  • 154
  • 2
Polyklonal

Konjugat

  • 235
  • 49
  • 25
  • 9
  • 7
  • 7
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser IL-1 beta Antikörper ist unkonjugiert

Applikation

  • 283
  • 177
  • 132
  • 132
  • 104
  • 54
  • 38
  • 18
  • 15
  • 14
  • 14
  • 13
  • 13
  • 11
  • 7
  • 6
  • 5
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 26
    • 24
    • 15
    • 15
    • 15
    • 12
    • 11
    • 9
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Sequenz

    MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL

    Homologie

    Dog: 92%, Horse: 86%, Human: 100%, Mouse: 75%, Rabbit: 92%

    Produktmerkmale

    This is a rabbit polyclonal antibody against IL1B. It was validated on Western Blot using a cell lysate as a positive control.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the N terminal region of human IL1B
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 269 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Lee, Lu, Chai, Sheu, Chen, Huang, Kao, Chen, Chung, Sung, Chang, Lee, Yip: "Circulating microparticles enhanced rat vascular wall remodeling following endothelial denudation." in: American journal of translational research, Vol. 8, Issue 11, pp. 4511-4522, (2016) (PubMed).

    Wang, Jiang, Li, He, Zhao, Yang, Zhu, Yin, Li, Wang, Liu, Shang, Yang, Wang, Zhen, Zhang, Yu, Zhong, Ye, Huang, Yuan: "Shigella flexneri T3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-?B p65 protein." in: Cellular microbiology, Vol. 15, Issue 3, pp. 474-85, (2013) (PubMed).

  • Target

    IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

    Andere Bezeichnung

    IL1B

    Hintergrund

    IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. The gene encoding IL1B and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
    Alias Symbols: IL-1, IL1-BETA, IL1F2
    Protein Interaction Partner: PTPN1, LYN, FYN, CMA1, CASP1, APP, SP1, EGR1, ELAVL1, CASP4, IL1RAP, PRTN3, IL1R2, IL1R1, IL1B, MMP2, ADRB2, A2M, UBE2N, ZNF675, MAPK8IP2,
    Protein Size: 269

    Molekulargewicht

    17 kDa

    Gen-ID

    3553

    NCBI Accession

    NM_000576, NP_000567

    UniProt

    P01584

    Pathways

    NF-kappaB Signalweg, Interferon-gamma Pathway, TLR Signalweg, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagie, Cancer Immune Checkpoints, Inflammasome
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