GBL Antikörper (AA 100-320)

Produktnummer ABIN5027338

Produktdetails anti-GBL Antikörper

Target: GBL (G protein beta subunit-like (GBL))

Bindungsspezifität: AA 100-320

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GBL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant LST8/GBL protein (amino acids 100-320) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1-3 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu GBL

Target: GBL (G protein beta subunit-like (GBL))

Andere Bezeichnung: LST8/GBL (GBL Produkte)

Synonyme: gbl antikoerper, lts8 antikoerper, GBL antikoerper, GbetaL antikoerper, LST8 antikoerper, POP3 antikoerper, WAT1 antikoerper, 0610033N12Rik antikoerper, AA409454 antikoerper, AI505104 antikoerper, AI851821 antikoerper, Gbl antikoerper, fi37e04 antikoerper, wu:fi37e04 antikoerper, zgc:55455 antikoerper, zgc:85668 antikoerper, MTOR associated protein, LST8 homolog L homeolog antikoerper, MTOR associated protein, LST8 homolog antikoerper, MTOR associated protein, LST8 homolog (S. cerevisiae) antikoerper, mlst8.L antikoerper, MLST8 antikoerper, Mlst8 antikoerper, mlst8 antikoerper

Hintergrund: MLST8 or GbL (G protein beta protein subunit-like) is a subunit of mTORC1 and mTORC2 which regulates cell growth and survival. Both mTORC1 and 2 are activated in response to growth factors or amino acids but mTORC2 is most likely insensitive towards nutrients. Within mTORC1, LST8 interacts directly with mTOR and helps to enhance its kinase activity. mTORC1 phosphorylates EIF4EBP1 and thereby releasing it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. LST8/GBL more or less ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.

Molekulargewicht: 38 kDa

Gen-ID: 64223

UniProt: Q9BVC4

Pathways: PI3K-Akt Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Autophagie, CXCR4-mediated Signaling Events, BCR Signaling, Warburg Effekt