TICAM1 Antikörper (C-Term)

Produktnummer ABIN501042

Der Kaninchen Polyklonal anti-TICAM1 Antikörper (ABIN501042) detektiert spezifisch TICAM1 in WB, IHC (p) und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TICAM1 Antikörper (C-Term) (ABIN501042)

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TICAM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-TICAM1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects TICAM1 / TRIF.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Ion exchange chromatography

Immunogen: TRIF antibody was raised against a peptide corresponding to 14 amino acids near the C- terminus of human TRIF.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 2 to 4 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu TICAM1

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Andere Bezeichnung: TICAM1 / TRIF

Hintergrund: TRIF is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TRIF, along with other molecules such as TIRP, TIRAP, and MyD88, serves as an adaptor protein to several of the TLR molecules. Following activation of TLR3 and TLR4, TRIF engages the kinase TBK1 and allows its subsequent activation of the interferon regulatory factor (IRF)-3 (5). TRIF is also involved in the activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (6).Synonyms: PRVTIRB, Proline-rich vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, TICAM-1, TIR domain-containing adapter molecule 1, Toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta

Gen-ID: 148022

NCBI Accession: NP_891549

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades