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eIF4EBP1 Antikörper (C-Term)

Dieses Anti-eIF4EBP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von eIF4EBP1 in WB, IF und EIA. Geeignet für Human und Maus.
Produktnummer ABIN499179

Kurzübersicht für eIF4EBP1 Antikörper (C-Term) (ABIN499179)

Target

Alle eIF4EBP1 (EIF4EBP1) Antikörper anzeigen
eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

Reaktivität

  • 217
  • 162
  • 118
  • 21
  • 14
  • 7
  • 5
  • 5
  • 5
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 234
  • 19
  • 4
Kaninchen

Klonalität

  • 219
  • 40
Polyklonal

Konjugat

  • 112
  • 24
  • 18
  • 10
  • 7
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
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  • 5
  • 5
  • 5
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
Dieser eIF4EBP1 Antikörper ist unkonjugiert

Applikation

  • 207
  • 85
  • 85
  • 66
  • 66
  • 42
  • 25
  • 25
  • 22
  • 17
  • 16
  • 8
  • 6
  • 5
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
  • Bindungsspezifität

    • 28
    • 20
    • 20
    • 19
    • 16
    • 15
    • 11
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    • 2
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    4E-BP1 antibody was raised against a 14 amino acid peptide from near the carboxy-terminus of human 4E-BP1.

    Aufreinigung

    Affinity chromatography purified via peptide column

    Immunogen

    A 14 amino acid peptide from near the carboxy-terminus of Human 4E-BP1

    Isotyp

    IgG
  • Applikationshinweise

    ELISA. Western Blot: 4E-BP1 antibody can be used for the detection of 4E-BP1 at 2.5 - 5 μg/mL. Immunofluorescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    PBS containing 0.02 % Sodium Azide as preservative

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store the antibody undiluted at 2-8 °C.
  • Target

    eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

    Andere Bezeichnung

    EIF4EBP1 / 4E-BP1

    Hintergrund

    The translation of mRNA in eukaryotic cells is regulated by the presence of amino acids through multiple mechanisms (reviewed in 1). One such mechanism involves the evolutionarily conserved serine/threonine kinase TOR (Target of rapamycin, also known as mTOR), which regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 2). One downstream target of TOR is the eukaryotic initiation factor 4E binding protein 1 (4E-BP1) whose phosphorylation prevents its association with eIF4E, preferentially stimulating translation of mRNAs containing long, highly structured 5'-UTRs (1). Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation (reviewed in 3), at least in part by inhibiting the activity of TOR towards 4E-BP1.Synonyms: Eukaryotic translation initiation factor 4E-binding protein 1, PHAS-1, PHAS-I, PHAS1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, eIF4E-binding protein 1

    Gen-ID

    1978

    NCBI Accession

    NP_004086

    UniProt

    Q13541

    Pathways

    MAPK Signalweg, PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, Regulation of Cell Size, BCR Signaling
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