MAP2K4 Antikörper (pSer80)

Produktnummer ABIN362192

Produktdetails anti-MAP2K4 Antikörper

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Bindungsspezifität: pSer80

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP2K4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Spezifität: The antibody detects endogenous level of SEK1/MKK4 only when phosphorylated at serine 80.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogen: Peptide sequence around phosphorylation site of pSer80 (T-H-S (p) -I-E) derived from Human SEK1, MKK4. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Referenzen für anti-MAP2K4 Antikörper (ABIN362192)

Saha, Jiang, Yang, Zhu, Wang, Schimmer, Qiu, Chang: "Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma." in: PLoS ONE, Vol. 7, Issue 1, pp. e30215, (2012) (PubMed).

Details zu MAP2K4

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Andere Bezeichnung: SEK1/MKK4 (MAP2K4 Produkte)

Synonyme: JNKK antikoerper, JNKK1 antikoerper, MAPKK4 antikoerper, MEK4 antikoerper, MKK4 antikoerper, PRKMK4 antikoerper, SAPKK-1 antikoerper, SAPKK1 antikoerper, SEK1 antikoerper, SERK1 antikoerper, SKK1 antikoerper, Sek1 antikoerper, Serk1 antikoerper, MKK4A-l antikoerper, map2k4 antikoerper, zgc:136500 antikoerper, jnkk antikoerper, mek4 antikoerper, mkk4 antikoerper, sek1 antikoerper, jnkk1 antikoerper, serk1 antikoerper, xmek2 antikoerper, mapkk4 antikoerper, prkmk4 antikoerper, 142758_at antikoerper, CG9738 antikoerper, CT27508 antikoerper, D-MKK4 antikoerper, DMKK4 antikoerper, Dmel\\CG9738 antikoerper, JNKK2 antikoerper, Mpk4 antikoerper, SEK1/MKK4 antikoerper, dMKK4 antikoerper, dMkk4 antikoerper, hep antikoerper, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 antikoerper, ATMEK4 antikoerper, ATMKK4 antikoerper, F19C24.26 antikoerper, F19C24_26 antikoerper, MAP KINASE KINASE 4 antikoerper, mitogen-activated protein kinase kinase 4 antikoerper, MKK4B antikoerper, zgc:194486 antikoerper, mitogen-activated protein kinase kinase 4 antikoerper, mitogen-activated protein kinase kinase 4a antikoerper, MAP kinase kinase 4 antikoerper, mitogen activated protein kinase kinase 4 antikoerper, mitogen-activated protein kinase kinase 4b antikoerper, MAP2K4 antikoerper, Map2k4 antikoerper, map2k4a antikoerper, map2k4 antikoerper, Mkk4 antikoerper, MKK4 antikoerper, map2k4b antikoerper

Hintergrund: Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).

Molekulargewicht: 44 kDa

NCBI Accession: NP_003001

UniProt: P45985

Pathways: MAPK Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling