p53 Antikörper (AA 1-110)

Produktnummer ABIN3020823

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch p53 in WB, IHC, IF, IP und ChIP. Er zeigt eine Reaktivität gegenüber Human und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für p53 Antikörper (AA 1-110) (ABIN3020823)

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p53 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP)

Produktdetails anti-p53 Antikörper

Bindungsspezifität: AA 1-110

Sequenz: MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human p53 (NP_000537.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,ChIP,1:50 - 1:100,IP,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-p53 Antikörper (ABIN3020823)

Feng, Yu, Liu, Zhang, Cheng, Li, Tan, Luo, Jiang: "KAT5 silencing induces apoptosis of GBC-SD cells through p38MAPK-mediated upregulation of cleaved Casp9." in: International journal of clinical and experimental pathology, Vol. 7, Issue 1, pp. 80-91, (2014) (PubMed).

Zhu, Wang, Yang, Guo, Li, Wang, Wang, Huang, Wang, Yang, Ma, Bi: "Comparison of toxicity of benzene metabolite hydroquinone in hematopoietic stem cells derived from murine embryonic yolk sac and adult bone marrow." in: PLoS ONE, Vol. 8, Issue 8, pp. e71153, (2013) (PubMed).

He, Zhang, Wang, Zhong, Shao, Zhu, Shen: "AURKA suppression induces DU145 apoptosis and sensitizes DU145 to docetaxel treatment." in: American journal of translational research, Vol. 5, Issue 3, pp. 359-67, (2013) (PubMed).

Bao, Lu, Bin, Chang, Meng, Zhou, Guo, Zhao: "Systematic screen with kinases inhibitors reveals kinases play distinct roles in growth of osteoprogenitor cells." in: International journal of clinical and experimental pathology, Vol. 6, Issue 10, pp. 2082-91, (2013) (PubMed).

Details zu p53

Target: p53 (TP53) (Tumor Protein P53 (TP53))

Andere Bezeichnung: TP53

Hintergrund: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).,BCC7,LFS1,P53,TRP53,p53,TP53,BMFS5,Epigenetics & Nuclear Signaling,Transcription Factors,DNA Damage & Repair,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,PI3K-Akt Signaling Pathway,ErbB-HER Signaling Pathway,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Cell Cycle,Cell cycle inhibitors,G1/S Checkpoint,G2/M DNA Damage Checkpoint,Endocrine & Metabolism,AMPK Signaling Pathway,Warburg Effect,Neuroscience,Neurodegenerative Diseases,TP53

Molekulargewicht: 23-43 kDa

Gen-ID: 7157

UniProt: P04637

Pathways: p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt