TRAF6 Antikörper (C-Term)

Produktnummer ABIN2779328

Produktdetails anti-TRAF6 Antikörper

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRAF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: FGYVTFMHLE ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDA

Homologie: Cow: 100%, Horse: 100%, Human: 100%, Mouse: 91%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TRAF6. It was validated on Western Blot.

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human TRAF6

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TRAF6

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Andere Bezeichnung: TRAF6 (TRAF6 Produkte)

Synonyme: MGC:3310 antikoerper, RNF85 antikoerper, 2310003F17Rik antikoerper, AI851288 antikoerper, C630032O20Rik antikoerper, rnf85 antikoerper, traf6 antikoerper, xtraf6 antikoerper, CG10961 antikoerper, DTRAF2 antikoerper, Dmel\\CG10961 antikoerper, TRAF antikoerper, TRAF2 antikoerper, TRAF6 antikoerper, Traf2 antikoerper, dTRAF2 antikoerper, dTRAF6 antikoerper, dTraf2 antikoerper, dtraf2 antikoerper, GB10539 antikoerper, fi15f02 antikoerper, wu:fi15f02 antikoerper, zgc:63704 antikoerper, TNF receptor associated factor 6 antikoerper, TNF receptor-associated factor 6 antikoerper, TNF receptor associated factor 6 L homeolog antikoerper, TNF-receptor-associated factor 6 antikoerper, TNF receptor associated factor 6 S homeolog antikoerper, TRAF6 antikoerper, Traf6 antikoerper, traf6.L antikoerper, traf6 antikoerper, LOC551819 antikoerper, traf6.S antikoerper

Hintergrund: TRAF6 is an E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. It also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. It may be essential for the formation of functional osteoclasts. It seems to also play a role in dendritic cells (DCs) maturation and/or activation. It represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. It regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.
Alias Symbols: MGC:3310, RNF85
Protein Interaction Partner: YES1, UBE2V1, UBE2N, UBE2L3, UBE2E1, UBE2D2, UBE2D1, POLI, UBC, IL1R1, EDARADD, PLEKHF2, LAT, TRAF3IP2, PPP4R1, USP2, IKBKG, TRAF6, TRAF5, TRAF2, TRAF1, CNTN2, SYK, VPS52, PSEN1, LGMN, MEOX2, MCL1, CANX, nef, TAB2, OTUD7A, GTF2I, KRAS, DCBLD2, MAP3K7, EIF
Protein Size: 522

Molekulargewicht: 57 kDa

Gen-ID: 7189

NCBI Accession: NM_004620, NP_004611

UniProt: Q9Y4K3

Pathways: NF-kappaB Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway