Parkin Antikörper (C-Term)

Produktnummer ABIN2775689

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Parkin in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Schwein und Hund.

Kurzübersicht für Parkin Antikörper (C-Term) (ABIN2775689)

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Parkin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Parkin Antikörper

Bindungsspezifität: C-Term

Sequenz: YTRYQQYGAE ECVLQMGGVL CPRPGCGAGL LPEQGQRKVT CEGGNGLGCG

Homologie: Cow: 92%, Dog: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against Park2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 464 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Parkin

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Andere Bezeichnung: Park2

Hintergrund: Park2 functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5 and AIMP2. Park2 may play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Park2 limits the production of reactive oxygen species (ROS). Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of AR-JP. Park2 may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. Park2 may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Park2 regulates cyclin E during neuronal apoptosis. Park2 may represent a tumor suppressor gene. Park2 promotes the autophagic degradation of dysfunctional depolarized mitochondria.
Alias Symbols: MGC130518, PRKN
Protein Interaction Partner: Becn1, Actb, Hdac6, TARDBP, Bax, Acta1, Ubc, Prps1, SNCA, Sh3gl2, Eps15, Synj1, Sh3gl3, Sh3gl1, Ambra1, Pick1, Cask, Abl1, Bcl2,
Protein Size: 464

Molekulargewicht: 51 kDa

Gen-ID: 50873

NCBI Accession: NM_016694, NP_057903

UniProt: Q9WVS6

Pathways: Autophagie, Ubiquitin Proteasome Pathway