IFNB1 Antikörper

Produktnummer ABIN2665499

Der Ziege Polyklonal anti-IFNB1 Antikörper (Klon Poly5192) (ABIN2665499) detektiert spezifisch IFNB1 in WB, IHC, IP, IF und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für IFNB1 Antikörper (ABIN2665499)

Target: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Reaktivität: Maus

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser IFNB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: Poly5192

Produktdetails anti-IFNB1 Antikörper

Aufreinigung: The antibody was purified by antigen-affinity chromatography.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu IFNB1

Target: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Andere Bezeichnung: IFN-beta

Hintergrund: Interferon-β is a member of the type I interferon class. Type I IFNs are involved in the innate immune system, being released non-specifically during the early stage of infection in response to stimuli such as viruses, dsRNA, LPS, and bacterial components. Once secreted by virus-infected or activated cells, they bind to the IFNα/β receptor (IFNAR), which is found on almost all cell types, and, via the JAK-STAT pathway, induce the expression of hundreds of IFN-stimulated genes (ISGs). While the function of many of these proteins remains to be elucidated, a hallmark of type I IFNs is their anti-viral activities, both general and specific against particular viruses. Type I IFNs also regulate cell growth and apoptosis, and exert various immunomodulatory and inflammatory effects. As such, they are also clinically relevant, both as therapeutics and as targets of inhibition for the treatment of various autoimmune diseases and cancer. Mouse IFN-β is a ~20 kD monomeric glycoprotein. It has 50 % amino acid sequence homology with mouse IFN-α, its closest related protein, and 62 % homology with human IFN-β. IFN-β is currently the therapeutic of choice for treating multiple sclerosis.

Pathways: JAK-STAT Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagie, Inflammasome