CD130/gp130 Antikörper

Produktnummer ABIN2664198

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch CD130/gp130 in WB, IHC, ELISA, IF, Neut, CyTOF und ICFC. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für CD130/gp130 Antikörper (ABIN2664198)

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD130/gp130 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Neutralization (Neut), Cytometry by Time of Flight (CyTOF), Intracellular Flow Cytometry (ICFC)

Klon: 4H1B35

Produktdetails anti-CD130/gp130 Antikörper

Aufreinigung: The antibody was purified by affinity chromatography.

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CD130/gp130

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Andere Bezeichnung: CD130

Hintergrund: CD130, also known as gp130 and IL-6ST, is a type I transmembrane glycoprotein. CD130 can form receptor complexes for a family of cytokines, which include IL-6, IL-11, IL-27, LIF, and OSM, and can transduce signals for these cytokines. The 597aa extracellular domain has one Ig-like domain and five fibronectin type-III repeats. The 277a.a. intracellular domain does not have intrinsic kinase activity. Instead, it can be phosphorylated at tyrosine residues after it forms complexes with other receptor subunits, and in turn can lead to the association with JAK tyrosine kinases and the activation of STAT transcription factors, particularly STAT3.

Pathways: JAK-STAT Signalweg, Cellular Glucan Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Cancer Immune Checkpoints