CD130/gp130 Antikörper

Produktnummer ABIN206053

Produktdetails anti-CD130/gp130 Antikörper

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD130/gp130 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Spezifität: Recognizes soluble and membrane bound gp130 receptor, also known as CD130, Interleukin-6 receptor subunit beta, Oncostatin-M receptor subunit alpha or Interleukin-6 signal transducer. CD130 is a 918 amino acid, ~130 kD single pass type-1 transmembrane glycoprotein containing a single and multiple domains. CD130 can be cleaved to form a monomeric soluble ~100 kD form of the receptor detectable in plasma and other biologic fluids where it acts as an IL-6 antagonist. Binds to an epitope dependent at least partially on the presence of the Ig-like domain. Has been reported to block receptor activity and inhibit IL-6 induced proliferation of XG1 cells and IL-27 mediated proliferation of naive CD4+ T cells,.

Aufreinigung: Ion exchange chromatography

Immunogen: Natural soluble gp130 receptor.

Type of Immunogen: Purified protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Approved: ELISA, Flo

Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Method sheets are available on request.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu CD130/gp130

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Andere Bezeichnung: CD130 / IL6ST / Gp130 (IL6ST Produkte)

Hintergrund: Name/Gene ID: IL6ST
Family: Interleukin

Synonyms: IL6ST, CD130, CD130 antigen, IL-6R subunit beta, IL-6 receptor subunit beta, Membrane glycoprotein gp130, Membrane glycoprotein 130, IL-6RB, CDW130, gp130, IL-6R-beta

Gen-ID: 3572

Pathways: JAK-STAT Signalweg, Cellular Glucan Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Cancer Immune Checkpoints