Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

p53 Antikörper (pSer9)

Dieses Anti-p53-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von p53 in WB, IF und DB. Geeignet für Human. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.
Produktnummer ABIN1881624

Kurzübersicht für p53 Antikörper (pSer9) (ABIN1881624)

Target

Alle p53 (TP53) Antikörper anzeigen
p53 (TP53) (Tumor Protein P53 (TP53))

Reaktivität

  • 968
  • 280
  • 232
  • 143
  • 75
  • 74
  • 60
  • 40
  • 10
  • 9
  • 9
  • 6
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 670
  • 324
  • 5
  • 2
  • 2
Kaninchen

Klonalität

  • 575
  • 427
  • 1
Polyklonal

Konjugat

  • 527
  • 51
  • 32
  • 20
  • 19
  • 18
  • 17
  • 17
  • 17
  • 17
  • 17
  • 17
  • 14
  • 14
  • 14
  • 14
  • 14
  • 14
  • 14
  • 14
  • 14
  • 12
  • 12
  • 11
  • 11
  • 11
  • 11
  • 11
  • 11
  • 10
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Dieser p53 Antikörper ist unkonjugiert

Applikation

  • 732
  • 323
  • 287
  • 241
  • 211
  • 142
  • 133
  • 129
  • 122
  • 119
  • 80
  • 64
  • 35
  • 20
  • 16
  • 12
  • 10
  • 9
  • 8
  • 6
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Dot Blot (DB)

Klon

RB7893
  • Bindungsspezifität

    • 39
    • 38
    • 38
    • 31
    • 31
    • 30
    • 26
    • 26
    • 24
    • 22
    • 21
    • 19
    • 19
    • 19
    • 19
    • 18
    • 18
    • 16
    • 14
    • 12
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    pSer9

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This P53 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S9 of human P53.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    IF: 1:10~50. WB: 1:1000. DB: 1:500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Blanchette, Cheng, Yan, Ketner, Ornelles, Dobner, Conaway, Conaway, Branton: "Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53." in: Molecular and cellular biology, Vol. 24, Issue 21, pp. 9619-29, (2004) (PubMed).

    Adachi, Toyota, Sasaki, Yamashita, Ishida, Ohe-Toyota, Maruyama, Hinoda, Saito, Imai, Kudo, Tokino: "Identification of SCN3B as a novel p53-inducible proapoptotic gene." in: Oncogene, Vol. 23, Issue 47, pp. 7791-8, (2004) (PubMed).

    Zhang, Wang, Chen, Zhang, Cheng, Heng, Wu, Shen: "Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells." in: The Journal of biological chemistry, Vol. 279, Issue 41, pp. 42545-51, (2004) (PubMed).

    Anazawa, Arakawa, Nakagawa, Nakamura: "Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway." in: Oncogene, Vol. 23, Issue 46, pp. 7621-7, (2004) (PubMed).

    Montagnoli, Tenca, Sola, Carpani, Brotherton, Albanese, Santocanale: "Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells." in: Cancer research, Vol. 64, Issue 19, pp. 7110-6, (2004) (PubMed).

  • Target

    p53 (TP53) (Tumor Protein P53 (TP53))

    Andere Bezeichnung

    P53

    Hintergrund

    Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.

    Molekulargewicht

    43653

    NCBI Accession

    NP_000537, NP_001119584, NP_001119585, NP_001119586, NP_001119587, NP_001119588, NP_001119589, NP_001119590, NP_001263624, NP_001263625, NP_001263626, NP_001263627, NP_001263628, NP_00126

    UniProt

    P04637

    Pathways

    p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt
Sie sind hier:
Chat with us!