Insulin Antikörper (AA 35-64)

Produktnummer ABIN1539839

Produktdetails anti-Insulin Antikörper

Target: Insulin (INS)

Bindungsspezifität: AA 35-64

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Insulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This INS antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 35-64 amino acids from human INS.

Klon: 396CT20-4-4

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: WB: 1:1000~8000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: INS Antibody (Ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu Insulin

Target: Insulin (INS)

Andere Bezeichnung: INS (INS Produkte)

Synonyme: IDDM2 antikoerper, ILPR antikoerper, IRDN antikoerper, MODY10 antikoerper, ins1 antikoerper, xins antikoerper, ins1-a antikoerper, Insulin antikoerper, AA986540 antikoerper, Ins-2 antikoerper, InsII antikoerper, Mody antikoerper, Mody4 antikoerper, proinsulin antikoerper, zgc:109842 antikoerper, igf2-A antikoerper, ins antikoerper, ins-a antikoerper, ins-b antikoerper, insulin antikoerper, insulin precursor antikoerper, insulin II antikoerper, preproinsulin antikoerper, insulin L homeolog antikoerper, insulin S homeolog antikoerper, INS antikoerper, INS-IGF2 antikoerper, ins antikoerper, Ins antikoerper, PIN antikoerper, Ins2 antikoerper, ins.L antikoerper, ins.S antikoerper

Hintergrund: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq].

Molekulargewicht: 11981

Gen-ID: 3630

NCBI Accession: NP_000198, NP_001172026, NP_001172027

UniProt: P01308

Pathways: NF-kappaB Signalweg, RTK Signalweg, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagie, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation