p53 Antikörper (AA 20-25) (Biotin)
-
- Target Alle p53 (TP53) Antikörper anzeigen
- p53 (TP53) (Tumor Protein P53 (TP53))
-
Bindungsspezifität
- AA 20-25
-
Reaktivität
- Human, Rind (Kuh), Pferd, Cat
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser p53 Antikörper ist konjugiert mit Biotin
-
Applikation
- Flow Cytometry (FACS)
- Spezifität
- This antibody recognizes the p53 tumour suppressor protein, binding to both wild type and mutant forms. Clone DO-1 binds to both wild type and mutant forms of the p53 protein found in various malignancies (Kern et al. 1992). p53 is important in multicellular organisms, where it regulates cell cycle progression to allow DNA repair or apoptosis in the case of irreparably damaged cells (Haupt et al. 2003) and thus functions as a tumor suppressor that is involved in preventing cancer. Mutations in the p53 gene are found in about half the cases of human cancer (Joerger and Fersht 2007). DO-1 recognizes an epitope at the N-terminal end of p53 between amino acids 20-25, common to isoforms 1-3 of p53.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human, Horse, Bovine, Cat, Green Monkey and Sheep.
- Aufreinigung
- Affinity chromatography on Protein G
- Immunogen
- Recombinant human p53. Spleen cells from immunised BALB/c mice were fused with cells of the mouse X63Ag8.653 myeloma cell line.
- Klon
- DO-1
- Isotyp
- IgG2a
- Top Product
- Discover our top product TP53 Primärantikörper
-
-
- Applikationshinweise
-
Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 0.1 mg/mL
- Buffer
- PBS, pH 7.4, 0.09 % Sodium Azide, 1 % BSA
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- Target
- p53 (TP53) (Tumor Protein P53 (TP53))
- Andere Bezeichnung
- p53 (TP53) (TP53 Produkte)
- Synonyme
- BCC7 antikoerper, LFS1 antikoerper, P53 antikoerper, TRP53 antikoerper, p53 antikoerper, Trp53 antikoerper, brp53 antikoerper, drp53 antikoerper, etID22686.5 antikoerper, fb40d06 antikoerper, wu:fb40d06 antikoerper, zgc:111919 antikoerper, Tp53 antikoerper, bbl antikoerper, bfy antikoerper, bhy antikoerper, p44 antikoerper, tp53 antikoerper, Xp53 antikoerper, TP53 antikoerper, tumor protein p53 antikoerper, cellular tumor antigen p53 antikoerper, transformation related protein 53 antikoerper, tumor protein p53 L homeolog antikoerper, TP53 antikoerper, CpipJ_CPIJ002758 antikoerper, Tp53 antikoerper, tp53 antikoerper, Trp53 antikoerper, tp53.L antikoerper
- Hintergrund
- Synonyms: Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
- Gen-ID
- 7157
- NCBI Accession
- NP_000537
- UniProt
- P04637
- Pathways
- p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt
-