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Phospholipase C gamma 2 Antikörper (pTyr759) (PE)

PLCG2 Reaktivität: Human, Ratte, Maus ICS Wirt: Maus Monoclonal K86-689-37 PE
Produktnummer ABIN1177149
  • Target Alle Phospholipase C gamma 2 (PLCG2) Antikörper anzeigen
    Phospholipase C gamma 2 (PLCG2)
    Bindungsspezifität
    • 31
    • 24
    • 16
    • 16
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr759
    Reaktivität
    • 133
    • 69
    • 55
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    Human, Ratte, Maus
    Wirt
    • 125
    • 8
    Maus
    Klonalität
    • 121
    • 12
    Monoklonal
    Konjugat
    • 60
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    Dieser Phospholipase C gamma 2 Antikörper ist konjugiert mit PE
    Applikation
    • 96
    • 40
    • 40
    • 36
    • 35
    • 23
    • 19
    • 18
    • 11
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    Intracellular Staining (ICS)
    Marke
    BD Phosflow™
    Aufreinigung
    Purified from tissue culture supernatant or ascites by affinity chromatography
    Immunogen
    Phosphorylated Human PLC-gamma2 Peptide
    Klon
    K86-689-37
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product PLCG2 Primärantikörper
  • Probenmenge
    20 μL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
  • Kim, Sekiya, Poulin, Bae, Rhee: "Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 9986-99, (2004) (PubMed).

  • Target
    Phospholipase C gamma 2 (PLCG2)
    Andere Bezeichnung
    PLC-gamma 2 (PLCG2 Produkte)
    Synonyme
    PLCgamma2 antikoerper, Plcg-2 antikoerper, APLAID antikoerper, FCAS3 antikoerper, phospholipase C, gamma 2 antikoerper, phospholipase C gamma 2 antikoerper, phospholipase C, gamma 2 (phosphatidylinositol-specific) antikoerper, Plcg2 antikoerper, PLCG2 antikoerper
    Hintergrund
    The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositol biphosphate to inositol triphosphate and diacylglycerol. The former causes release of calcium from the endoplasmic reticulum, while the latter is an activator of Protein Kinase C. Within the PLC family, PLC-gamma is the only member that contains SH2 and SH3 domains. These domains enable it to interact with protein tyrosine kinases and become enzymatically activated via phosphorylation. It exists as two isoforms: PLC-g1, which is ubiquitously expressed, and PLC-g2, which is found primarily in the hematopoietic system. PLC-g2-null mice exhibit impaired B lymphocyte maturation and defects in Fc receptor functions. Phosphorylation of PLC-g2 at tyrosines 753 and 759 (Y759) is required for activation of PLC-g2 enzyme activity. PLC-g2 phosphorylation at Y759 can be induced by stimulation of the B cell receptor in Ramos cells, the collagen receptor in platelets, and the T cell receptor in Jurkat cells, and it occurs downstream of Btk and BLNK in the signaling cascade of activated B cells. The K86-689.37.73 antibody recognizes PLC-g2 phosphorylated at Y759 in the SH2-SH3 linker region.
    Pathways
    RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades, VEGF Signaling, BCR Signaling
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